Document Detail


Antimicrobial peptides: an essential component of the skin defensive barrier.
MedLine Citation:
PMID:  16909919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The skin is positioned at the interface between an organism's internal milieu and an external environment characterized by constant assault with potential microbial pathogens. While the skin was formerly considered an inactive physical protective barrier that participates in host immune defense merely by blocking entry of microbial pathogens, it is now apparent that a major role of the skin is to defend the body by rapidly mounting an innate immune response to injury and microbial insult. In the skin, both resident and infiltrating cells synthesize and secrete small peptides that demonstrate broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses. Antimicrobial peptides also act as multifunctional immune effectors by stimulating cytokine and chemokine production, angiogenesis, and wound healing. Cathelicidins and defensins comprise two major families of skin-derived antimicrobial peptides, although numerous others have been described. Many such immune defense molecules are currently being developed therapeutically in an attempt to combat growing bacterial resistance to conventional antibiotics.
Authors:
M H Braff; R L Gallo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current topics in microbiology and immunology     Volume:  306     ISSN:  0070-217X     ISO Abbreviation:  Curr. Top. Microbiol. Immunol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-16     Completed Date:  2006-08-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0110513     Medline TA:  Curr Top Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  91-110     Citation Subset:  IM    
Affiliation:
University of California, San Diego 92161, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimicrobial Cationic Peptides / physiology*
Defensins / physiology*
Humans
Immunity, Innate*
Immunologic Factors / physiology
Keratinocytes / immunology
Skin / immunology*
Skin Diseases, Bacterial / immunology
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Defensins; 0/Immunologic Factors; 143108-26-3/CAP18 lipopolysaccharide-binding protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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