| Antimicrobial peptide from spider venom inhibits Chlamydia trachomatis infection at an early stage. | |
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MedLine Citation:
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PMID: 23277388 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Antichlamydial activity of cyto-insectotoxin 1a (CIT 1a), representative of a unique class of antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi, was studied. A plasmid vector expressing the cit 1a gene controlled by a human cytomegalovirus tetracycline-dependent promoter was constructed. Impressive inhibition of Chlamydia trachomatis infection in HEK 293 cells transfected by the cit 1a-harboring vector was achieved. With the use of various schemes of cell infection and gene expression induction, it was shown for the first time that an antimicrobial peptide exerts its potent antichlamydial action at an early stage of the pathogen life cycle. |
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Authors:
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Vassili N Lazarev; Marina M Shkarupeta; Nadezhda F Polina; Elena S Kostrjukova; Alexander A Vassilevski; Sergey A Kozlov; Eugene V Grishin; Vadim M Govorun |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-1 |
Journal Detail:
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Title: Archives of microbiology Volume: - ISSN: 1432-072X ISO Abbreviation: Arch. Microbiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410427 Medline TA: Arch Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Research Institute for Physico-Chemical Medicine of the Federal Medical and Biological Agency of Russian Federation, 1a, Malaya Pirogovskaya St., 119435, Moscow, Russia, lazar0@mail.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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