Document Detail


Antimicrobial peptide from spider venom inhibits Chlamydia trachomatis infection at an early stage.
MedLine Citation:
PMID:  23277388     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Antichlamydial activity of cyto-insectotoxin 1a (CIT 1a), representative of a unique class of antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi, was studied. A plasmid vector expressing the cit 1a gene controlled by a human cytomegalovirus tetracycline-dependent promoter was constructed. Impressive inhibition of Chlamydia trachomatis infection in HEK 293 cells transfected by the cit 1a-harboring vector was achieved. With the use of various schemes of cell infection and gene expression induction, it was shown for the first time that an antimicrobial peptide exerts its potent antichlamydial action at an early stage of the pathogen life cycle.
Authors:
Vassili N Lazarev; Marina M Shkarupeta; Nadezhda F Polina; Elena S Kostrjukova; Alexander A Vassilevski; Sergey A Kozlov; Eugene V Grishin; Vadim M Govorun
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-1
Journal Detail:
Title:  Archives of microbiology     Volume:  -     ISSN:  1432-072X     ISO Abbreviation:  Arch. Microbiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410427     Medline TA:  Arch Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Research Institute for Physico-Chemical Medicine of the Federal Medical and Biological Agency of Russian Federation, 1a, Malaya Pirogovskaya St., 119435, Moscow, Russia, lazar0@mail.ru.
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