Document Detail

Antimicrobial gentamicin activity in the presence of exogenous protease inhibitor (Bowman-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats.
MedLine Citation:
PMID:  1528344     Owner:  NLM     Status:  MEDLINE    
In our previous studies, we found increased levels of urinary trypsin inhibitory activity in gentamicin-induced nephrotoxicity in rats. Following administration of the Bowman-Birk trypsin and chymotrypsin inhibitor (BBI), no proteinuria was detected in gentamicin-treated rats, and a decrease in creatinine clearance was noted in only 50% of the injected rats. In the present study, we examined the antimicrobial activity of gentamicin against Escherichia coli in the presence of BBI in gentamicin-induced nephrotoxicity in rats. We found that 50% of rats with E. coli-positive blood cultures died of septicemia. All the rats injected with E. coli plus gentamicin or E. coli plus gentamicin plus BBI survived, the latter showing no proteinuria or deterioration in creatinine clearance. In conclusion, BBI, which is an effective inhibitor of gentamicin-induced nephrotoxicity, does not affect the antimicrobial activity of gentamicin sulfate.
S Smetana; S Khalef; Y Bar-Khayim; Y Birk
Related Documents :
3363224 - Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clot...
8280784 - Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria f...
25000184 - Magnetic resonance colonography for fibrosis assessment in rats with chronic colitis.
2140034 - Multiple isoelectric variants of copper, zinc-superoxide dismutase from rat liver.
12711024 - Tamoxifen administration and metabolism in nude mice and nude rats.
19420984 - Comparison of the potency of lidocaine and chloroprocaine in sciatic nerve block in spr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  61     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Nephrology Unit, Wolfson Hospital, Holon, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Creatinine / metabolism
Escherichia coli Infections / drug therapy*
Gentamicins / pharmacokinetics,  therapeutic use*,  toxicity*
Kidney / drug effects,  pathology,  physiopathology*
Rats, Inbred Strains
Sepsis / drug therapy*
Trypsin / metabolism
Trypsin Inhibitor, Bowman-Birk Soybean / pharmacology*
Reg. No./Substance:
0/Gentamicins; 0/Trypsin Inhibitor, Bowman-Birk Soybean; 60-27-5/Creatinine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pseudouridine excretion in healthy subjects and its accumulation in renal failure.
Next Document:  Low urine citrate excretion as main risk factor for recurrent calcium oxalate nephrolithiasis in mal...