Document Detail


Antimicrobial gentamicin activity in the presence of exogenous protease inhibitor (Bowman-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats.
MedLine Citation:
PMID:  1528344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In our previous studies, we found increased levels of urinary trypsin inhibitory activity in gentamicin-induced nephrotoxicity in rats. Following administration of the Bowman-Birk trypsin and chymotrypsin inhibitor (BBI), no proteinuria was detected in gentamicin-treated rats, and a decrease in creatinine clearance was noted in only 50% of the injected rats. In the present study, we examined the antimicrobial activity of gentamicin against Escherichia coli in the presence of BBI in gentamicin-induced nephrotoxicity in rats. We found that 50% of rats with E. coli-positive blood cultures died of septicemia. All the rats injected with E. coli plus gentamicin or E. coli plus gentamicin plus BBI survived, the latter showing no proteinuria or deterioration in creatinine clearance. In conclusion, BBI, which is an effective inhibitor of gentamicin-induced nephrotoxicity, does not affect the antimicrobial activity of gentamicin sulfate.
Authors:
S Smetana; S Khalef; Y Bar-Khayim; Y Birk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  61     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Affiliation:
Nephrology Unit, Wolfson Hospital, Holon, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Creatinine / metabolism
Escherichia coli Infections / drug therapy*
Female
Gentamicins / pharmacokinetics,  therapeutic use*,  toxicity*
Kidney / drug effects,  pathology,  physiopathology*
Proteinuria
Rats
Rats, Inbred Strains
Sepsis / drug therapy*
Trypsin / metabolism
Trypsin Inhibitor, Bowman-Birk Soybean / pharmacology*
Chemical
Reg. No./Substance:
0/Gentamicins; 0/Trypsin Inhibitor, Bowman-Birk Soybean; 60-27-5/Creatinine; EC 3.4.21.4/Trypsin

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