Document Detail


Antimicrobial enzymes: An emerging strategy to fight microbes and microbial biofilms.
MedLine Citation:
PMID:  23281326     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
With the increasing prevalence of antibiotic resistance, antimicrobial enzymes aimed at the disruption of bacterial cellular machinery and biofilm formation are under intense investigation. Several enzyme-based products have already been commercialized for application in the healthcare, food and biomedical industries. Successful removal of complex biofilms requires the use of multi-enzyme formulations that contain enzymes capable of degrading microbial DNA, polysaccharides, proteins and quorum-sensing molecules. The inclusion of anti-quorum sensing enzymes prevents biofilm reformation. The development of effective complex enzyme formulations is urgently needed to deal with the problems associated with biofilm formation in manufacturing, environmental protection and healthcare settings. Nevertheless, advances in synthetic biology, enzyme engineering and whole DNA-Sequencing technologies show great potential to facilitate the development of more effective antimicrobial and anti-biofilm enzymes.
Authors:
Barbara Thallinger; Endry N Prasetyo; Gibson S Nyanhongo; Georg M Guebitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biotechnology journal     Volume:  8     ISSN:  1860-7314     ISO Abbreviation:  Biotechnol J     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265833     Medline TA:  Biotechnol J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  97-109     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Graz University of Technology, Institute of Environmental Biotechnology, Graz, Austria.
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