| Antimicrobial efficacy of 0.05% cetylpyridinium chloride mouthrinses. | |
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MedLine Citation:
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PMID: 23039819 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: This study evaluated the antimicrobial activity of two commercially-available 0.05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a control fluoride mouthrinse without CPC. MATERIALS AND RESULTS: Two different approaches were used to evaluate antimicrobial activity. First, the minimum inhibitory concentration (MIC) was determined for each mouthrinse against a panel of 25 micro-organisms including species associated with dental caries, gingivitis and periodontitis. Second, supragingival dental plaque obtained from 15 adults was incubated with the four mouthrinses to evaluate antimicrobial activity on micro-organisms in oral biofilms. Both CPC mouthrinses exhibited lower MIC's, that is, greater antimicrobial activity, against oral gram-negative bacteria especially periodontal pathogens and species implicated in halitosis such as Aggregatibacter actinomycemcomitans, Campylobacter rectus, Eikenella corrodens, Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei than the control mouthrinse. Ex-vivo tests on supragingival plaque micro-organisms demonstrated significantly greater antimicrobial activity by the CPC mouthrinses (>90% killing, p<0.001) and the chlorhexidine rinse (>98% killing, p<0.05) compared to the control fluoride mouthrinse. CONCLUSIONS: While the chlorhexidine mouthrinse was most effective, mouthrinses containing 0.05% CPC formulated with or without alcohol demonstrated broad-spectrum antimicrobial activity against both laboratory strains and supragingival plaque bacteria compared to a control mouthrinse without CPC. SIGNIFICANCE AND IMPACT OF STUDY: These in vitro and ex vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque-associated gingivitis. © 2012 The Authors Letters in Applied Microbiology © 2012 The Society for Applied Microbiology. |
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Authors:
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P K Sreenivasan; V I Haraszthy; J J Zambon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
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Title: Letters in applied microbiology Volume: - ISSN: 1472-765X ISO Abbreviation: Lett. Appl. Microbiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510094 Medline TA: Lett Appl Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Letters in Applied Microbiology © 2012 The Society for Applied Microbiology. |
Affiliation:
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Colgate Palmolive Company, Piscataway, NJ, USA. |
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