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Antimicrobial effects of Burow's solution on Staphylococcus aureus and Pseudomonas aeruginosa.
MedLine Citation:
PMID:  22718290     Owner:  NLM     Status:  In-Data-Review    
Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. We demonstrated that Burow's solution had antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa, inducing ultrastructural changes in these bacteria in vitro. S. aureus strain 209P and P. aeruginosa strain IID1130 were treated with 13% Burow's solution. Viable cell counts were determined to measure bactericidal effects. Ultrastructural changes in cells of both strains were examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Viable cell counting revealed that S. aureus cells treated with Burow's solution were killed within 30 min. The viable cell count of P. aeruginosa was reduced by 1 × 10(7) colony-forming units/ml (CFU/ml) after a 60-min treatment. SEM examination of S. aureus revealed blebbing on the surface of bacterial cells, whereas TEM revealed undulating deformation of the bacterial cell wall, diluted cytoplasm, and cell membrane detachment. SEM observations of P. aeruginosa revealed a more apparent undulating deformation of the bacterial cell surface. TEM observations also revealed deformations in the bacterial cell wall and diluted cytoplasm in both bacteria. These findings show that Burow's solution is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Yukiyoshi Hyo; Sakuo Yamada; Masaki Ishimatsu; Kenji Fukutsuji; Tamotsu Harada
Publication Detail:
Type:  Journal Article     Date:  2012-06-21
Journal Detail:
Title:  Medical molecular morphology     Volume:  45     ISSN:  1860-1499     ISO Abbreviation:  Med Mol Morphol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239023     Medline TA:  Med Mol Morphol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
Department of Otolaryngology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan,
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