Document Detail

Antimicrobial constituents of Rhus glabra.
MedLine Citation:
PMID:  8072309     Owner:  NLM     Status:  MEDLINE    
The antimicrobial activity of the methanol extract and isolated constituents of Rhus glabra (Anacardiaceae), a species used in folk medicine by North American native people, was evaluated against 11 microorganisms, including gram-positive and gram-negative bacteria. The extract was subsequently fractionated and monitored by bioassays leading to the isolation of three antibacterial compounds, the methyl ester of 3,4,5-trihydroxybenzoic acid (methyl gallate) (minimal inhibition concentration (MIC) 12.5 micrograms/ml), 4-methoxy-3,5-dihydroxybenzoic acid (MIC 25 micrograms/ml) and gallic acid (MIC > 1000 micrograms/ml). The first two compounds are reported here for the first time from Rhus glabra. Their structures were established using spectroscopic and chemical methods.
G Saxena; A R McCutcheon; S Farmer; G H Towers; R E Hancock
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  42     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-23     Completed Date:  1994-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Department of Botany, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Anti-Bacterial Agents / isolation & purification*,  pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology
Chromatography, High Pressure Liquid
Escherichia coli / drug effects
Gallic Acid / analogs & derivatives,  isolation & purification,  pharmacology
Indians, North American*
Medicine, Traditional*
Microbial Sensitivity Tests
Plant Extracts / isolation & purification,  pharmacology
Plants, Toxic*
Pseudomonas aeruginosa / drug effects
Staphylococcus aureus / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 149-91-7/Gallic Acid; 4319-02-2/3,5-dihydroxy-4-methoxybenzoic acid; 99-24-1/methyl gallate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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