Document Detail

Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria.
MedLine Citation:
PMID:  19469289     Owner:  NLM     Status:  MEDLINE    
Catnip (Nepeta cataria) is an important medicinal herb belonging to the mint family, Lamiaceae. In this study, the in vitro antimicrobial and antioxidant activities of the essential oil and methanol extract from Nepeta cataria, and its essential oil composition were investigated. The essential oil, which has 4aalpha,7alpha,7abeta-nepetalactone (70.4%), 4aalpha,7alpha,7abeta-nepetalactone (6.0%), thymol (2.3%), and 4aalpha,7alpha, 7abeta3-nepetalactone (2.5%), as main components, exhibited activity against eleven bacteria, and twelve fungi and a yeast, C. albicans; with Minimum Inhibitory Concentrations (MIC) values ranging from 12.50 to 250 microl/ml; the methanol extract showed weaker activity. The samples were also subjected to a screening for their possible antioxidant activities by using 2.2-diphenyl-1-picrylhydrazyl (DPPH) and beta-carotene/linoleic acid assays. In DPPH assay, the extract showed slight antioxidant activity whereas the essential oil remained inactive. In the latter case, both the extract and the essential oil exerted weak activity having inhibiton ratios of linoleic acid oxidation at 16.4% and 27.0%, respectively. The weak antioxidative nature of the extract could be attributed to the low phenolic content, estimated as gallic acid equivalent at 22.6 +/- 2.07 microg/ml or 2.26%. In both systems, antioxidant capacity of BHT was determined in parallel experiments.
Ahmet Adiguzel; Hakan Ozer; Munevver Sokmen; Medine Gulluce; Atalay Sokmen; Hamdullah Kilic; Fikrettin Sahin; Ozlem Baris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists     Volume:  58     ISSN:  1733-1331     ISO Abbreviation:  Pol. J. Microbiol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229003     Medline TA:  Pol J Microbiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Health Services Vocational Training School, Ataturk University, Yenisehir-Erzurum, 25070, Turkey.
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MeSH Terms
Anti-Infective Agents / pharmacology*
Antioxidants / metabolism*
Bacteria / drug effects
Biphenyl Compounds / metabolism
Cyclopentanes / pharmacology
Fungi / drug effects
Gas Chromatography-Mass Spectrometry
Linoleic Acid / metabolism
Methanol / chemistry
Microbial Sensitivity Tests
Picrates / metabolism
Plant Extracts / metabolism,  pharmacology*
Plant Oils / chemistry,  metabolism,  pharmacology*
Pyrones / pharmacology
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antioxidants; 0/Biphenyl Compounds; 0/Cyclopentanes; 0/Picrates; 0/Plant Extracts; 0/Plant Oils; 0/Pyrones; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 21651-62-7/nepetalactone; 2197-37-7/Linoleic Acid; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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