Document Detail

Antimicrobial and antioxidant activities of some Nigerian medicinal plants.
MedLine Citation:
PMID:  20162089     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Ten Nigerian plants suggested from their ethnomedical uses to possess antimicrobial and antioxidant activities were studied for their anti-microbial and anti-oxidant properties. Antimicrobial activity was tested against Escherichia coli NCTC 10418, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Candida pseudotropicalis and Trichophyton rubrum (clinical isolate). Trichilia heudelotti leaf extract showed both antibacterial and antifungal activities and was the most active against all the strains of bacteria tested. Boerhavia diffusa, Markhamia tomentosa and T. heudelotti leaf extracts inhibited the gram negative bacteria E. coli and P. aeruginosa strains whereas those of M. tomentosa, T. heudelotti and Sphenoceutrum jollyamum root inhibited at least one of the fungi tested. At a concentration of 312 microg/ml, hexane and chloroform fractions of T. heudelotti extract inhibited 6 and 14% of the fifty multi-drug resistant bacteria isolates from clinical infections, respectively. At < or = 5 mg/ml, the CHCl(3) (64%) and aqueous (22%) fractions of T. heudelotti and those of CHCl(3) (34%) and EtOAC (48%) of M. tomentosa gave the highest inhibition that was stronger than their corresponding methanol extracts. The corresponding EC(50) of the extracts on M. acuminata, T. heudelotti, E. senegalensis and M. tomentosa were 4.00, 6.50, 13.33, and 16.50 ig/ml using the TLC staining and 1,1-dipheyl-2-picry-hydrazyl (DPPH) free radical scavenging assay. Therefore, leaf extracts of M. tomentosa and T. heudelotti, especially the latter, possess strong antimicrobial and antioxidant activities and should be further investigated. These activities justified the ethnomedical uses of these plants.
A J Aladesanmi; E O Iwalewa; A C Adebajo; E O Akinkunmi; B J Taiwo; F O Olorunmola; A Lamikanra
Related Documents :
22821309 - Antimicrobial susceptibility patterns of multidrug-resistant pseudomonas aeruginosa and...
20201279 - Chemical composition and in vitro antimicrobial activity of essential oil of melissa of...
25378459 - Influence of virulence genotype and resistance profile in the mortality of pseudomonas ...
15664479 - Antimicrobial susceptibility of uncommonly isolated non-enteric gram-negative bacilli.
15833239 - Isolation, molecular characterization and antimicrobial resistance patterns of salmonel...
17353239 - Covalent dimer species of beta-defensin defr1 display potent antimicrobial activity aga...
25475279 - Effects of osmotic pressure, acid, or cold stresses on antibiotic susceptibility of lis...
12887239 - Evaluation of the antimicrobial efficacy of urinary catheters impregnated with antisept...
6345579 - New serogroup of legionella pneumophila, serogroup 8.
Publication Detail:
Type:  Journal Article     Date:  2006-11-13
Journal Detail:
Title:  African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines     Volume:  4     ISSN:  0189-6016     ISO Abbreviation:  Afr J Tradit Complement Altern Med     Publication Date:  2006  
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101232990     Medline TA:  Afr J Tradit Complement Altern Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  173-84     Citation Subset:  -    
Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevention of radiation induced hematological alterations by medicinal plant Rosmarinus officinalis,...
Next Document:  Evaluation of the antimicrobial properties of different parts of citrus aurantifolia (lime fruit) as...