Document Detail

Antimicrobial activity of tigecycline against recent isolates of respiratory pathogens from Asian countries.
MedLine Citation:
PMID:  16631337     Owner:  NLM     Status:  MEDLINE    
In vitro activities of tigecycline were compared with 15 other comparator agents against recent clinical isolates of respiratory pathogens (623 Streptococcus pneumoniae, 105 Staphylococcus aureus, 92 Klebsiella pneumoniae, and 84 Haemophilus influenzae isolates) collected from 11 Asian countries. All isolates of S. pneumoniae from Asian countries were susceptible to tigecycline regardless of penicillin susceptibility with MIC90 of <or=0.06 mg/L. Both methicillin-resistant and methicillin-susceptible S. aureus isolates were susceptible to tigecycline with very low MIC90 values (0.25 and 0.12 mg/L, respectively). Tigecycline was also active against K. pneumoniae (98.9% susceptible; MIC50, 1 mg/L; MIC90, 2 mg/L) including 10 extended-spectrum beta-lactamase-producing isolates and H. influenzae (100% susceptible; MIC50 and MIC90, 0.12 mg/L) from Korea. Data confirmed that tigecycline has an excellent in vitro activity against drug-resistant clinical isolates of respiratory pathogens from Asian countries.
Kwan Soo Ko; Jae-Hoon Song; Mi Young Lee; Sulhee Park; Ki Tae Kwon; Sang Taek Heo; Seong Yeol Ryu; Won Sup Oh; Kyong Ran Peck; Nam Yong Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-02
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  55     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-04     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Bacterial / drug effects
Haemophilus influenzae / drug effects
Klebsiella pneumoniae / drug effects
Methicillin Resistance / drug effects
Microbial Sensitivity Tests
Minocycline / analogs & derivatives*,  pharmacology
Respiratory Tract Diseases / drug therapy,  microbiology*
Staphylococcus aureus / drug effects
Streptococcus pneumoniae / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/tigecycline; 10118-90-8/Minocycline

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