Document Detail

Antimicrobial activity of stereoisomers of butane-type lignans.
MedLine Citation:
PMID:  19661689     Owner:  NLM     Status:  MEDLINE    
The relationship between the stereochemistry and antimicrobial activity of butane-type lignans was clarified. All stereoisomers of dihydroguaiaretic acid (DGA) showed both antibacterial and antifungal activity. The (+)- and (-)-7,7'-dioxodihydroguaiaretic acid (ODGA) also showed both antibacterial and antifungal activity, while meso-ODGA did not show antibacterial activity, but showed antifungal activity. No activity of any stereoisomer of secoisolariciresinol (SECO) was apparent.
Yuya Kawaguchi; Satoshi Yamauchi; Kenta Masuda; Hisashi Nishiwaki; Koichi Akiyama; Masafumi Maruyama; Takuya Sugahara; Taro Kishida; Yojiro Koba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  73     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1806-10     Citation Subset:  IM    
Faculty of Agriculture, Ehime University, Japan.
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MeSH Terms
Anti-Infective Agents / chemical synthesis,  chemistry*,  pharmacology*
Bacteria / drug effects
Butanes / chemistry*
Foodborne Diseases / microbiology
Fungi / drug effects
Guaiacol / analogs & derivatives*,  chemical synthesis,  chemistry,  pharmacology
Lignans / chemical synthesis,  chemistry*,  pharmacology*
Plant Diseases / microbiology
Structure-Activity Relationship
Substrate Specificity
Reg. No./Substance:
0/Anti-Infective Agents; 0/Butanes; 0/Lignans; 106-97-8/butane; 36469-60-0/dihydroguaiaretic acid; 90-05-1/Guaiacol

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