| Antimicrobial activity of some new thioureides derived from 2-(4-chlorophenoxymethyl)benzoic acid. | |
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MedLine Citation:
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PMID: 18463566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report here the characterisation of eight newly synthesized thioureides of 2-(4-chlorophenoxymethyl)-benzoic acid and the evaluation of the in vitro antimicrobial activity of the new compounds against Gram-positive [Listeria monocytogenes,Staphylococcus aureus, Bacillus subtilis], Gram-negative [Psedomonas aeruginosa,Escherichia coli, Salmonella enteritidis], as well as Candida spp., using both reference and clinical multidrug resistant strains to establish the minimal inhibitory concentration (MIC)values. Our results showed that the tested compounds exhibited specific antimicrobial activities, both concerning the spectrum of antimicrobial activity and the corresponding MIC values, which ranged widely between 1024 and 32 mug/mL, depending on the nature and position of the substituents on the benzene ring. The most active compounds were N-[2-(4-chlorophenoxymethyl)-benzoyl]-N'-(2,6-dichlorophenyl)-thiourea (5 g) and N-[2-(4-chlorophenoxymethyl)-benzoyl]-N'-(4-bromophenyl)-thiourea (5h), which showed a broad spectrum of antimicrobial activity against enterobacterial strains (E. coli and S. enteritidis),P. aeruginosa, S. aureus and Candida spp. All the tested compounds except 5f were highly active against S. aureus (MIC=32 mug/mL), suggesting their possible use in the treatment of MRSA infections. Four of compounds also exhibited antifungal activity (MIC =256-32 microg/mL) against C. albicans, but L. monocytogenes as well as B. subtilis were resistant to all tested compounds. Our studies thus demonstrated that among other biological activities,the thioureides of 2-(4-chlorophenoxymethyl)-benzoic acid also exhibit selective and effective antimicrobial properties that could lead to the selection and use of these compounds as efficient antimicrobial agents, especially for the treatment of multidrug resistant infections. |
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Authors:
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Carmen Limban; Mariana-Carmen Balotescu Chifiriuc; Alexandru-Vasile Missir; Ileana Cornelia Chiriţă; Coralia Bleotu |
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Publication Detail:
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Type: Journal Article Date: 2008-03-04 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 13 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-08 Completed Date: 2008-11-03 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 567-80 Citation Subset: IM |
Affiliation:
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Pharmaceutical Chemistry Department, Faculty of Farmacy, Carol Davila University of Medicine and Pharmacy, Traian Vuia 6, sect. 2, 020956, Bucharest, Romania. carmen_chifiriuc@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Annexin A5
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metabolism Anti-Bacterial Agents / chemical synthesis, chemistry, pharmacology* Antifungal Agents / chemical synthesis, chemistry, pharmacology Bacteria / drug effects Benzoic Acid / chemical synthesis, chemistry, pharmacology* Benzoic Acids / chemical synthesis*, chemistry, pharmacology* Flow Cytometry Fungi / drug effects Hela Cells Humans Hydrocarbons, Fluorinated / chemical synthesis*, chemistry, pharmacology* Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Thiourea / chemical synthesis*, chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/2-(4-chlorophenoxymethyl)benzoic acid; 0/Annexin A5; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Benzoic Acids; 0/Hydrocarbons, Fluorinated; 62-56-6/Thiourea; 65-85-0/Benzoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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