Document Detail


Antimicrobial activity of some hydroxamic acids.
MedLine Citation:
PMID:  16375829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several hydroxamic acids, viz., N-benzyl-N'-hydroxysuccinamide (BHS), poly[alpha,beta-(N-hydroxy)-DL-aspartamide] (PHA), poly[alpha,beta-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) and poly[alpha,beta-(N-hydroxy)-DL- aspartamide]/poly[alpha,beta-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) were prepared and screened for their antimicrobial activity. Ten Gram-positive and 7 Gram-negative species of bacteria, 5 Candida species, 4 dermatophyte species and 3 mould species were used in tests. Compound showed no antimicrobial activity on any of the tested microorganisms. Other compounds showed a narrow spectrum of antibacterial activity, but no antifungal activity.
Authors:
Stjepan Pepeljnjak; Branka Zorc; Ivan Butula
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmaceutica (Zagreb, Croatia)     Volume:  55     ISSN:  1330-0075     ISO Abbreviation:  Acta Pharm     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-26     Completed Date:  2006-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9303678     Medline TA:  Acta Pharm     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  401-8     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. spep33@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents / chemical synthesis,  pharmacology*
Aspartic Acid / analogs & derivatives,  chemical synthesis
Colony Count, Microbial
Disinfectants / chemical synthesis,  pharmacology
Gram-Negative Bacteria / drug effects,  growth & development
Gram-Positive Bacteria / drug effects,  growth & development
Hemolytic Plaque Technique
Hydroxamic Acids / chemical synthesis,  pharmacology*
Microbial Sensitivity Tests
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Disinfectants; 0/Hydroxamic Acids; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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