| Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15. | |
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MedLine Citation:
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PMID: 2517587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid derivatives substituted on carbon-15. Only acetylgrandifloric acid (ent-kaur-16-en-15 alpha-acetyloxy-19-oic) and its epimer xylopic acid (ent-kaur-16-en-15 beta-acetyloxy-19-oic) displayed significant antibacterial activity at concentrations greater than or equal to 250 micrograms/ml, the 15 alpha epimer being the most active. |
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Authors:
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S C Davino; A M Giesbrecht; N F Roque |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 22 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-06-27 Completed Date: 1990-06-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 1127-9 Citation Subset: IM |
Affiliation:
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Departamento de Farmacologia, Universidade de São Paulo, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus cereus
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drug effects Brazil Chemical Phenomena Chemistry Diterpenes / pharmacology* Fungi / drug effects* Microbial Sensitivity Tests Plant Extracts / pharmacology Plants, Medicinal Staphylococcus aureus / drug effects Staphylococcus epidermidis / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/Plant Extracts; 14696-30-1/kaur-16-en-15-ol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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