Document Detail

Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15.
MedLine Citation:
PMID:  2517587     Owner:  NLM     Status:  MEDLINE    
The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid derivatives substituted on carbon-15. Only acetylgrandifloric acid (ent-kaur-16-en-15 alpha-acetyloxy-19-oic) and its epimer xylopic acid (ent-kaur-16-en-15 beta-acetyloxy-19-oic) displayed significant antibacterial activity at concentrations greater than or equal to 250 micrograms/ml, the 15 alpha epimer being the most active.
S C Davino; A M Giesbrecht; N F Roque
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  22     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-06-27     Completed Date:  1990-06-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1127-9     Citation Subset:  IM    
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
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MeSH Terms
Bacillus cereus / drug effects
Chemical Phenomena
Diterpenes / pharmacology*
Fungi / drug effects*
Microbial Sensitivity Tests
Plant Extracts / pharmacology
Plants, Medicinal
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects
Reg. No./Substance:
0/Diterpenes; 0/Plant Extracts; 14696-30-1/kaur-16-en-15-ol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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