Document Detail

Antimicrobial activity of essential oils against Helicobacter pylori.
MedLine Citation:
PMID:  12752733     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Helicobacter pylori is an important pathogen responsible for gastroduodenal diseases in humans. Although the eradication of H. pylori using antibiotics often improves gastroduodenal diseases, resistance to the antibiotics is emerging. MATERIALS AND METHODS: The antimicrobial effect of essential oils and the development of resistance to the essential oils were evaluated in vitro and in vivo. RESULTS: Thirteen essential oils used in this study completely inhibited the growth of H. pylori in vitro at a concentration of 0.1% (v/v). Cymbopogon citratus (lemongrass) and Lippia citriodora (lemon verbena) were bactericidal against H. pylori at 0.01% at pH 4.0 and 5.0. Resistance to lemongrass did not develop even after 10 sequential passages, whereas resistance to clarithromycin developed under the same conditions. In in vivo studies, the density of H. pylori in the stomach of mice treated with lemongrass was significantly reduced compared with untreated mice. CONCLUSIONS: These results demonstrate that the essential oils are bactericidal against H. pylori without the development of acquired resistance, suggesting that essential oils may have potential as new and safe agents for inclusion in anti-H. pylori regimens.
Tomoyuki Ohno; Masakazu Kita; Yoshio Yamaoka; Shigeyoshi Imamura; Toshiro Yamamoto; Shoji Mitsufuji; Tadashi Kodama; Kei Kashima; JirO Imanishi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Helicobacter     Volume:  8     ISSN:  1083-4389     ISO Abbreviation:  Helicobacter     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9605411     Medline TA:  Helicobacter     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-15     Citation Subset:  IM    
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Clarithromycin / pharmacology
Drug Resistance, Bacterial
Helicobacter Infections / drug therapy*
Helicobacter pylori / drug effects*
Hydrogen-Ion Concentration
Microbial Sensitivity Tests
Oils, Volatile / pharmacology*
Plant Oils / pharmacology
Terpenes / pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Buffers; 0/Oils, Volatile; 0/Plant Oils; 0/Terpenes; 8007-02-1/lemongrass oil; 81103-11-9/Clarithromycin

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