Document Detail

Antimicrobial activity of coffee melanoidins-a study of their metal-chelating properties.
MedLine Citation:
PMID:  19123814     Owner:  NLM     Status:  MEDLINE    
Melanoidins comprise a substantial proportion of severely heat-treated foods such as baked cereals or roasted coffee and are widely consumed dietary components. The antimicrobial activity of coffee melanoidins against different pathogenic bacteria has been studied, finding that such activity is due to their metal-chelating properties. Three different mechanisms have been observed: at low concentrations melanoidins exerted a bacteriostatic activity mediated by iron chelation from the culture medium; in the case of bacterial strains that are able to produce siderophores for iron acquisition, melanoidins chelate the siderophore-Fe3+ complex, which could decrease the virulence of such pathogenic bacteria; and, finally, coffee melanoidins also exerted a bactericide activity at high concentrations by removing Mg2+ cations from the outer membrane, promoting the disruption of the cell membrane and allowing the release of intracellular molecules.
José A Rufián-Henares; Silvia P de la Cueva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  57     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-8     Citation Subset:  IM    
Departamento de Nutrición y Bromatología, Universidad de Granada, Spain.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  pharmacology
Bacteria / chemistry,  drug effects*
Chelating Agents / chemistry,  pharmacology*
Coffee / chemistry*
Iron / chemistry*
Plant Extracts / chemistry,  pharmacology
Polymers / chemistry*,  pharmacology
Siderophores / chemistry
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Chelating Agents; 0/Coffee; 0/Plant Extracts; 0/Polymers; 0/Siderophores; 0/melanoidin polymers; 7439-89-6/Iron

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