| Antimicrobial and Anticoagulant Activity of N-chlorotaurine (NCT), N,N-dichloro-2,2-dimethyltaurine (NVC-422) and N-monochloro-2,2-dimethyltaurine (NVC-612) in Human Blood. | |
| | |
MedLine Citation:
|
PMID: 22252818 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this study was to determine the potential application of N-chlorotaurine (NCT), N,N-dichloro-2,2- dimethyltaurine (NVC-422) and N-chloro-2,2-dimethyltaurine (NVC-612) as catheter-lock solutions for the prevention of catheter blockage and catheter-related bloodstream infections by testing their anticoagulant and broad-spectrum antimicrobial activity in human blood.NCT, NVC-422 and NVC-612 and control compounds were serially diluted in fresh human blood to evaluate the effects on prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, and direct thrombin inhibition. Quantitative killing assays against pathogens including methicillin-resistant Staphylococcus aureus, Escherichia coli and Candida albicans were performed in the presence of heparin and human blood.NCT, NVC-612 (1.38 mM each), and 1.02 mM NVC-422 prolonged prothrombin time (Quick value 17 - 30%), activated partial thromboplastin time 3- to 4-fold to 76-125 sec, and thrombin time 2- to 4-fold to 34 to 68 sec. Fibrinogen decreased from 258 to 283 mg/dl (range of controls) to < 40 mg/dl. No direct thrombin inhibition was observed by NVC-422 or NVC-612. Heparin did not influence the bactericidal activity of NCT. The microbicidal activity of NCT, NVC-422 and NVC-612 was maintained in diluted human blood.NCT, NVC-612 and NVC-422 have broad-spectrum antimicrobial activity in blood and anticoagulant activity targeting both intrinsic and extrinsic pathways of the coagulation system. These properties support their application as catheter-lock solutions. |
| | |
Authors:
|
C Martini; A Hammerer-Lercher; M Zuck; A Jekle; D Debabov; M Anderson; M Nagl |
Related Documents
:
|
7779458 - A biologically-based algorithm for predicting human tissue: blood partition coefficient... 2079098 - Intravenously infused adenosine increases the blood flow to brown adipose tissue in rats. 16303838 - Human skeletal muscle lipolysis is more responsive to epinephrine than to norepinephrin... 2777668 - Histological evidence for nonperfused vasculature in a murine tumor following hydralazi... 22107748 - Distal pancreatectomy with en bloc celiac axis resection performed while monitoring hep... 8312658 - Spa bathing activates fibrinolysis in patients with cerebral infarction. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
|
Title: Antimicrobial agents and chemotherapy Volume: - ISSN: 1098-6596 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A genome-wide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal ...
Next Document: Population Pharmacokinetics of Metronidazole Using Scavenged Samples from Preterm Infants.