| Antimalarials and cholesterol profile of patients with systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 21779713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A beneficial influence of antimalarials on lipid profile of systemic lupus erythematosus (SLE) patients has been recently claimed. In this cross-sectional study, we evaluated the effect of chloroquine on cholesterol levels of a Brazilian population with SLE. Sixty patients were studied, 95% females. Mean age was 48.7 years (SD 13.3 years). Overweight or obesity was documented in 27 cases (45%). Thirty-four patients (56.6%) were using chloroquine in standard dosage, while 33 (55%) were on corticosteroids. Hypercholesterolemia was present in 26 patients (43.3%), while low HDL cholesterol levels were seen in 18 cases (30%). Normal cholesterolemia was documented equally in users and non-users of antimalarials (P > 0.20). After adjustment for statin and corticosteroid intake by multivariate analysis, cholesterol and HDL-cholesterol levels did not significantly differ in users or non-users of chloroquine (P > 0.05). There was no association of chloroquine intake with low body mass index (P = 0.314). Our findings suggest that antimalarial intake by itself does not distinguish cholesterol profiles in SLE patients. |
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Authors:
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Carina Rossoni; Melissa Cláudia Bisi; Mauro Waldemar Keiserman; Henrique Luiz Staub |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista brasileira de reumatologia Volume: 51 ISSN: 1809-4570 ISO Abbreviation: Rev Bras Reumatol Publication Date: 2011 Jul-Aug |
Date Detail:
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Created Date: 2011-07-22 Completed Date: 2011-12-08 Revised Date: 2012-05-08 |
Medline Journal Info:
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Nlm Unique ID: 0404256 Medline TA: Rev Bras Reumatol Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 383-4, 386-7 Citation Subset: IM |
Affiliation:
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Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul – PUC-RS, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimalarials
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therapeutic use* Chloroquine / therapeutic use* Cholesterol / blood* Cross-Sectional Studies Female Humans Lupus Erythematosus, Systemic / blood*, drug therapy* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 54-05-7/Chloroquine; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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