| Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei. | |
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MedLine Citation:
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PMID: 1541684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The polyunsaturated fatty acids docosahexaenoic acid (C22:6,n-3), eicosapentaenoic acid, arachidonic acid, and linoleic acid caused marked in vitro growth inhibition of Plasmodium falciparum, assessed by a radiometric assay. In contrast, negligible parasite killing was seen with oleic acid or docosanoic acid. Parasite killing was significantly increased when oxidized forms of polyunsaturated fatty acids were used. Antioxidants greatly reduced the fatty acid-induced killing. Mice infected with P. berghei and treated for 4 d with C22:6,n-3 showed marked reduction in parasitemia. The anemia associated with the infection was also alleviated by treatment with C22:6,n-3. The data provide new information that could be explored in order to develop new strategies in malaria treatment. |
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Authors:
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L M Kumaratilake; B S Robinson; A Ferrante; A Poulos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 89 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-04-07 Completed Date: 1992-04-07 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 961-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Immunology, Adelaide Children's Hospital, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimalarials / pharmacology* Antioxidants / pharmacology Fatty Acids, Unsaturated / pharmacology* Female Fish Oils / pharmacology* Malaria / drug therapy Mice Mice, Inbred BALB C Oxidation-Reduction Plasmodium berghei / drug effects* Plasmodium falciparum / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Antioxidants; 0/Fatty Acids, Unsaturated; 0/Fish Oils |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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