| Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams. | |
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MedLine Citation:
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PMID: 22221756 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf. METHODS: The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies. RESULTS: The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg). CONCLUSIONS: The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy. |
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Authors:
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Akuodor Godwin Christian; Amos Grace Mfon; Essien Augustine Dick; Essien David-Oku; Akpan Joseph Linus; Ezeokpo Basil Chukwuma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of tropical medicine Volume: 5 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 126-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department Pharmacology, College of Medical Sciences, University of Calabar, Nigeria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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