Document Detail


Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams.
MedLine Citation:
PMID:  22221756     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.
METHODS: The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.
RESULTS: The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).
CONCLUSIONS: The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
Authors:
Akuodor Godwin Christian; Amos Grace Mfon; Essien Augustine Dick; Essien David-Oku; Akpan Joseph Linus; Ezeokpo Basil Chukwuma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of tropical medicine     Volume:  5     ISSN:  1995-7645     ISO Abbreviation:  Asian Pac J Trop Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101533720     Medline TA:  Asian Pac J Trop Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  126-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department Pharmacology, College of Medical Sciences, University of Calabar, Nigeria.
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