Document Detail


Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance.
MedLine Citation:
PMID:  17251084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Before a recommendation for antimalarial drug use in pregnancy is made, it is essential that we understand the potential risks involved and have mechanisms in place to monitor risk during treatment. This requires data on drug disposition during pregnancy and potential toxicological liabilities to the developing fetus and mother. In most cases this information is not available. We review the reproductive toxicology of the main antimalarial drug classes in use or under development. Preclinical data are presented if appropriate, but as human experience overrides such data, in instances in which preclinical studies do not correlate with the human experience the data are reviewed only briefly. Additionally, we highlight the lack of appropriate drug disposition data in pregnancy and suggest mechanisms that can be used to capture data on risk after drug treatment in pregnancy.
Authors:
Stephen A Ward; Esperanca J P Sevene; Ian M Hastings; François Nosten; Rose McGready
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Lancet infectious diseases     Volume:  7     ISSN:  1473-3099     ISO Abbreviation:  Lancet Infect Dis     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130150     Medline TA:  Lancet Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-44     Citation Subset:  IM    
Affiliation:
Liverpool School of Tropical Medicine, Liverpool, UK. saward@liv.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials* / adverse effects,  pharmacokinetics,  therapeutic use
Female
Humans
Malaria, Falciparum / drug therapy*,  prevention & control
Mice
Pregnancy
Pregnancy Complications, Parasitic / drug therapy*,  prevention & control
Rats
Chemical
Reg. No./Substance:
0/Antimalarials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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