| Antimalarial drugs, pregnancy and lactation. | |
| | |
MedLine Citation:
|
PMID: 8485567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Disease activity has been demonstrated to be one of the major factors contributing to fetal loss in SLE patients, and discontinuation of antimalarial therapy can precipitate a flare of disease. It is therefore important to determine whether it is safe to continue antimalarial therapy throughout pregnancy. We have previously stated that we consider lupus patients and their fetuses to be at risk for disaster if antimalarial therapy is discontinued during pregnancy, and it has been our experience that lupus patients can produce normal offspring even if they are taking daily chloroquine or hydroxychloroquine. Several other reports now support our findings that it is probably safe to continue antimalarial therapy during pregnancy, although there are no large studies published. Data on the secretion of hydroxychloroquine in the breast milk of patients on steady-state hydroxychloroquine therapy are minimal, and further studies are required to determine whether these women can safely nurse their infants while taking hydroxychloroquine daily. |
| | |
Authors:
|
A L Parke |
Related Documents
:
|
2248137 - Detection of truncated dystrophin in fetal dmd myotubes. 10968047 - The occurrence of autoantibodies in sera of healthy pregnant women. 2691157 - Pregnancy in systemic lupus erythematosus. 18499707 - Bidirectional effects on autoimmunity and reproduction. 18442997 - Factors affecting low birthweight after assisted reproduction technology: difference be... 18366447 - Steady-state nevirapine plasma concentrations are influenced by pregnancy. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Lupus Volume: 2 Suppl 1 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 1993 Feb |
Date Detail:
|
Created Date: 1993-06-04 Completed Date: 1993-06-04 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9204265 Medline TA: Lupus Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: S21-3 Citation Subset: IM |
Affiliation:
|
University of Connecticut Health Center, Department of Medicine, Farmington, CT 06030-1310. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antimalarials
/
adverse effects,
pharmacokinetics,
therapeutic use* Female Humans Lactation Lupus Erythematosus, Systemic / drug therapy* Milk, Human / metabolism Pregnancy Pregnancy Complications / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Antimalarials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ophthalmologic safety profile of antimalarial drugs.
Next Document: The efficacy of antimalarials in systemic lupus erythematosus.