Document Detail


Antilipoprotein antibodies in rheumatoid arthritis.
MedLine Citation:
PMID:  8342045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antibodies against very low-density lipoproteins and low-density lipoproteins (aLA) were found in 26 of 69 (38%) patients with active rheumatoid arthritis (RA) but not in any control subjects (ie, 40 patients with psoriatic arthritis, 21 patients with osteoarthritis, and 65 healthy blood donors). In 21 RA patients (30%), lipoproteins were found in the dissociated components of circulating immune complexes. RA patients with aLA had significantly decreased cholesterol levels in all lipoprotein fractions and total serum lipids, while serum triglycerides were significantly increased compared with RA patients without aLA. Anticardiolipin antibodies as measured by the Venereal Disease Research Laboratory test were not found in any subject in this study. These findings suggest a possible autoimmune origin of dyslipoproteinemia in some patients with active RA.
Authors:
M B Lazarevic; J Vitic; B L Myones; V Mladenovic; N Nanusevic; J L Skosey; W I Swedler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  22     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-91     Citation Subset:  IM    
Affiliation:
Institute for Rheumatology, Medical School of Belgrade, Yugoslavia.
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MeSH Terms
Descriptor/Qualifier:
Antibodies / blood*
Antibodies, Anticardiolipin / blood
Arthritis, Rheumatoid / blood,  immunology*
Female
Humans
Lipoproteins / blood*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Anticardiolipin; 0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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