| Antilipemic and hypocholesteremic activities of Globimetula braunii in rats. | |
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MedLine Citation:
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PMID: 20619620 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Antilipemic/hypocholestermic activities of the methanolic extracts of Globimetula braunii were studied in the tissues of normo and hypercholesteremic rats. Hypercholesteremia was induced in the rats by feeding with dietary cholesterol at a dose of 40mg/kg body weight. A significant increase (p<0.05) was observed in the body and the visceral organs relative weights in all the groups. There was a significant decrease in HDL-cholesterol and a significant increase in the levels of LDL, total cholesterol and triglycerides in hypercholesteremic rats when compared to normo rats. Administration of the methanolic extracts restored the elevated levels of serum lipids to normal. The methanolic extracts of G. braunii produced a significant (p<0.05) decrease in the levels of total cholesterol, triglyceride, LDL-cholesterol and lipid peroxidation of the extract treated group compared to hypercholesteremic control. There was a significant (p<0.05) increase in the levels of HDL-cholesterol as compared to hypercholesteremic control. The results obtained from this study are indications of the antilipemic and hypocholestermic activities of G. braunii as well as its cardio-protective potential in normo and hypercholesteremia conditions. |
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Authors:
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Ochuko L Erukainure; Joseph A Abovwe; Adeniyi S Adefegha; Rabiat U Egwuche; Michael A Fafunso |
Publication Detail:
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Type: Journal Article Date: 2010-07-09 |
Journal Detail:
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Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 63 ISSN: 1618-1433 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
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Food Technology Division, Federal Institute of Industrial Research, P.M.B. 21023, Ikeja, Lagos, Nigeria. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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