Document Detail


Antiischemic and hemodynamic effects of an oral single dose of 150 mg of the phosphodiesterase inhibitor enoximone in patients with coronary artery disease--relation to plasma concentration.
MedLine Citation:
PMID:  1832289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic and antiischemic effects of a 150-mg single oral dose of the PDE inhibitor enoximone were correlated with the plasma levels of enoximone and its sulfoxide metabolite. Twenty-one patients with angiographically documented coronary artery disease were investigated by exercise testing 1 and 2 hours after drug administration. The control group consisted of 15 patients with proven coronary artery disease and stable reproducible angina pectoris on exercise. The enoximone group included 14 responders with therapeutic plasma concentrations 2 hours after drug intake and significantly reduced mean pulmonary artery pressures on exercise (from 42.4 +/- 8.6 to 30.9 +/- 11.2 mmHg, p less than 0.05). Compared to basal exercise values, responders showed a reduced ST-segment depression by 1 hour after drug intake (2.1 +/- 1.2 vs. 1.3 +/- 3 mm, p less than 0.05) and minimal values after 2 hours (0.9 +/- 1.0 mm, p less than 0.01) at comparable workloads. There were no significant changes in heart rate, blood pressure, cardiac output, and systemic vascular resistance. No significant improvement in the hemodynamic parameters and ST-segment depression was found in nonresponders with plasma concentrations below 100 ng/ml and 500 mg/ml for enoximone and its metabolite, respectively. In summary, oral administration of enoximone in patients with coronary artery disease led to favorable acute hemodynamic and antiischemic effects at sufficiently high plasma levels of enoximone and its sulfoxide metabolite.
Authors:
V Mitrovic; O Petrovic; H Bahavar; J Neuzner; H A Dieterich; M Schlepper
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  5     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-15     Completed Date:  1991-10-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-95     Citation Subset:  IM    
Affiliation:
Kerckhoff-Klinik of the Max-Planck Society, Bad Nauheim, FRG.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Cardiotonic Agents / administration & dosage*,  therapeutic use
Coronary Disease / drug therapy*
Electrocardiography / drug effects
Enoximone
Female
Hemodynamics / drug effects*
Humans
Imidazoles / administration & dosage*,  blood,  therapeutic use
Male
Middle Aged
Phosphodiesterase Inhibitors / administration & dosage*,  therapeutic use
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Imidazoles; 0/Phosphodiesterase Inhibitors; 77671-31-9/Enoximone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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