| Antiirritant properties of polyols and amino acids. | |
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MedLine Citation:
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PMID: 21569743 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background:Antiirritants are used in cosmetic products to prevent or to treat skin irritations that arise during daily life. Data were published earlier on the efficacy of the best-known humectant, glycerol, in reducing irritation.Objective:The aim of the present study was to examine the effects of different polyols (including glycerol, xylitol, and mannitol) and the amino acids taurine and glycine on sodium lauryl sulfate (SLS)-induced skin irritation.Methods:Healthy adult volunteers were patch-tested with 0.1% SLS in the presence or absence of one or another polyol or amino acid. Skin reactions were evaluated via measurements of transepidermal water loss (TEWL).Results:Glycerol and xylitol significantly suppressed the SLS-induced increase in TEWL, whereas mannitol had no effect on the SLS-induced skin irritation. Taurine also inhibited the SLS-induced increase in TEWL, but glycine was not effective in reducing the SLS-induced irritative response.Conclusion:Similar to the action of the well-known antiirritant glycerol, SLS-induced skin irritation is suppressed by xylitol and taurine. These results suggest that these agents might also be effective in preventing irritative dermatitis. |
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Authors:
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Csilla Korponyai; Réka K Kovács; Gábor Erös; Shabtay Dikstein; Lajos Kemény |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group Volume: 22 ISSN: 1710-3568 ISO Abbreviation: Dermatitis Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101207335 Medline TA: Dermatitis Country: Canada |
Other Details:
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Languages: eng Pagination: 141-6 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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