Document Detail

Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13.
MedLine Citation:
PMID:  8985204     Owner:  NLM     Status:  MEDLINE    
Plasma concentrations of soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13 were measured in 42 patients with clinically defined sepsis during a 3-day follow-up and in 7 healthy humans after intravenous injection of endotoxin (2 ng/kg). Levels of soluble IL-1 receptor type II were persistently elevated in patients with sepsis than in healthy controls and higher in nonsurviving patients (n = 22) than in surviving patients (n = 20) at all time points. IL-10 was found in the circulation of 81% of patients with sepsis, while it was not detectable in normal plasma. During follow-up, IL-10 remained invariably high only in nonsurviving patients, while it significantly decreased in survivors. Endotoxin induced IL-10, while soluble IL-1 receptor type II remained unchanged. IL-13 remained undetectable in the vast majority of patients and was not induced by endotoxin. Enhanced IL-13 production does not seem to be part of an inducible host defense mechanism during sepsis.
T van der Poll; R de Waal Malefyt; S M Coyle; S F Lowry
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  175     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-01-27     Completed Date:  1997-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  118-22     Citation Subset:  AIM; IM    
Cornell University Medical College, Department of Surgery, New York, New York 10021, USA.
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MeSH Terms
Aged, 80 and over
Endotoxemia / blood*
Interleukin-10 / blood*
Interleukin-13 / blood*
Middle Aged
Receptors, Interleukin-1 / blood*
Sepsis / blood*
Grant Support
Reg. No./Substance:
0/Interleukin-13; 0/Receptors, Interleukin-1; 130068-27-8/Interleukin-10

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