| Antihypertensive treatment and serum cholesterol: results of population-based surveys in the German Cardiovascular Prevention Study. | |
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MedLine Citation:
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PMID: 9553999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed the data from three cross-sectional, population-based surveys in West Germany to evaluate the effect of antihypertensive drug therapy on the level of serum cholesterol in German residents (18,344 males; 19,137 females) aged 25-69 years, after excluding persons with missing values (N = 5529) for any study variable. The data were obtained from the national and regional health surveys that were conducted during the years 1984-1992, within the framework of the German Cardiovascular Prevention Study (GCP). The response rates were between 66.0% and 71.4% for the national surveys and between 65.9% and 83.3% for the regional surveys. Blood-pressure and non-fasting cholesterol measurements were carried out under strictly standardized conditions. Multiple linear regression analysis was used to compare the age-adjusted mean value and prevalence for each of the following study variables: total serum cholesterol, HDL-cholesterol, non-HDL cholesterol, and the ratio of HDL cholesterol/total cholesterol for users and non-users of antihypertensive medications. Antihypertensive medications were reportedly taken during the seven days preceding the survey examination by 7.8% of all males and 10.4% of all females. The beta-blocker type of medication was prescribed most frequently for lowering high blood pressure. In both genders, the strongest age-adjusted effect of an increase in cholesterol level was found for beta-blockers. The difference in the age-adjusted means for non-HDL cholesterol values between users and non-users of beta-blockers was 9.2 mg/dL (p < 0.001) in males and 9.0 mg/dL (p < 0.001) in females. Regression analysis carried out to control for several potential confounders confirmed the results. The findings suggest that mass treatment of hypertension with beta-blockers may be associated with reductions in benefit because of an increase in non-HDL and a decrease in HDL cholesterol levels. |
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Authors:
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U Helmert; S Shea |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reviews on environmental health Volume: 12 ISSN: 0048-7554 ISO Abbreviation: Rev Environ Health Publication Date: 1997 Oct-Dec |
Date Detail:
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Created Date: 1998-05-29 Completed Date: 1998-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425754 Medline TA: Rev Environ Health Country: ISRAEL |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM |
Affiliation:
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Department for Health Policy, Occupational and Social Medicine, Bremen University, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology,
therapeutic use Adult Aged Antihypertensive Agents / pharmacology*, therapeutic use Cardiovascular Diseases / prevention & control Cholesterol / analysis, blood* Cholesterol, HDL / analysis, blood Cross-Sectional Studies Female Germany Health Surveys Humans Hypertension / drug therapy* Male Middle Aged Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Cholesterol, HDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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