| Antihypertensive treatment based on home or office blood pressure--the THOP trial. | |
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MedLine Citation:
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PMID: 15564986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE AND METHODS: In this randomized clinical trial, conducted in 400 hypertensive patients [sitting diastolic blood pressure (DBP) >95 mmHg], blood pressure-lowering therapy was adjusted in a stepwise manner, either on the basis of the self-measured DBP at home or on the basis of conventional DBP measured at the doctor's office. RESULTS: Therapy guided by home blood pressure instead of office blood pressure led to less intensive drug treatment and marginally lower costs, but also to less blood pressure control with no differences in left ventricular mass. Self-measurement helped to identify patients with white-coat hypertension. CONCLUSIONS: The present findings support a stepwise strategy for the evaluation of blood pressure, in which self-measurement and ambulatory monitoring are complementary to conventional office blood pressure measurement. |
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Authors:
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Elly Den Hond; Jan A Staessen; Hilde Celis; Robert Fagard; Louis Keary; Guy Vandenhoven; Eoin T O'Brien; |
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Publication Detail:
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Type: Clinical Trial; Consensus Development Conference; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Blood pressure monitoring Volume: 9 ISSN: 1359-5237 ISO Abbreviation: Blood Press Monit Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-26 Completed Date: 2005-05-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 311-4 Citation Subset: IM |
Affiliation:
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Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / therapeutic use* Blood Pressure Monitoring, Ambulatory* Female Humans Hypertension / diagnosis*, drug therapy* Male Middle Aged Physicians' Offices Randomized Controlled Trials as Topic / methods |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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