Document Detail

Antihypertensive treatment based on home or office blood pressure--the THOP trial.
MedLine Citation:
PMID:  15564986     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE AND METHODS: In this randomized clinical trial, conducted in 400 hypertensive patients [sitting diastolic blood pressure (DBP) >95 mmHg], blood pressure-lowering therapy was adjusted in a stepwise manner, either on the basis of the self-measured DBP at home or on the basis of conventional DBP measured at the doctor's office. RESULTS: Therapy guided by home blood pressure instead of office blood pressure led to less intensive drug treatment and marginally lower costs, but also to less blood pressure control with no differences in left ventricular mass. Self-measurement helped to identify patients with white-coat hypertension. CONCLUSIONS: The present findings support a stepwise strategy for the evaluation of blood pressure, in which self-measurement and ambulatory monitoring are complementary to conventional office blood pressure measurement.
Elly Den Hond; Jan A Staessen; Hilde Celis; Robert Fagard; Louis Keary; Guy Vandenhoven; Eoin T O'Brien;
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Publication Detail:
Type:  Clinical Trial; Consensus Development Conference; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  9     ISSN:  1359-5237     ISO Abbreviation:  Blood Press Monit     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-26     Completed Date:  2005-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure Monitoring, Ambulatory*
Hypertension / diagnosis*,  drug therapy*
Middle Aged
Physicians' Offices
Randomized Controlled Trials as Topic / methods
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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