| Antihypertensive therapy: role of aldosterone antagonists. | |
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MedLine Citation:
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PMID: 16026292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interest for the therapeutic potential of aldosterone antagonists in essential hypertension comes from the recently discovered nonclassical pathways of aldosterone actions, above all the presence of extra-adrenal aldosterone production and the discovery of aldosterone's proinflammatory and profibrotic actions. The review begins with the discussion of experimental studies on animals, demonstrating the role of aldosterone in cardiovascular remodeling and the effects of aldosterone blockade on hypertensive target organ damage. Then recent clinical studies are presented, that confirm in humans the deleterious role of aldosterone, in particular in the development of myocardial hypertrophy, cardiovascular fibrosis and arterial stiffness. After a brief description of the new selective aldosterone antagonist, eplerenone, compared to the well-known non-selective aldosterone antagonist, spironolactone, the results of studies on essential hypertensive patients are discussed, evaluating the efficacy of aldosterone antagonists in lowering blood pressure, but, more important, in protecting against target organ damage. |
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Authors:
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Anna Maria Grandi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current pharmaceutical design Volume: 11 ISSN: 1381-6128 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-07-19 Completed Date: 2006-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2235-42 Citation Subset: IM |
Affiliation:
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Professor of Internal Medicine, Department of Clinical Medicine, University of Insubria, Varese, Italy. amgrandi@libero.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology Aldosterone Antagonists / therapeutic use* Animals Antihypertensive Agents / therapeutic use* Humans Hypertension / drug therapy, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Antihypertensive Agents; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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