| Antihypertensive therapy in renal patients - benefits and difficulties. | |
| | |
MedLine Citation:
|
PMID: 10529626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High blood pressure values, diastolic and systolic, are associated with decreased renal function. This is particularly true when the diastolic blood pressure is higher than 90 mm Hg. Several studies showed that lowering of the blood pressure within the range of normotension according to the WHO causes a reduction in the rate of progression to terminal renal failure. These studies have led to recommendations to aim at a target blood pressure of approximately 125/75 mm Hg in the treatment of patients with glomerular diseases and particularly diabetic nephropathy with proteinuria >1 g/day. In contrast to these results, blood pressure values corresponding to the recommendation (</=125/75 mm Hg) of the JNC VI (see text) were achieved in 15% of the patients only. It has also been shown that at any given level of an average 24-hour blood pressure, patients with an insufficient decrease of the blood pressure during nighttime have a higher risk to progress to terminal renal failure. Thus it is very important to lower the nighttime blood pressure and to detect nighttime blood pressure increases using ambulatory blood pressure measurements. |
| | |
Authors:
|
V Schwenger; M Zeier; E Ritz |
Related Documents
:
|
6666616 - Renal blood flow during unilateral ureteral obstruction. effects of reduced perfusion p... 8743516 - Blood pressure and progression of renal failure in the elderly. 2929066 - Reversible renal hypertension due to renal hygroma. 7554426 - Nitric oxide inhibition does not prevent the hypotensive response to increased renal pe... 274316 - Comparison of induced and spontaneous arousals in hibernating hedgehogs. 21898116 - Should β blockers no longer be considered first-line therapy for the treatment of esse... |
Publication Detail:
|
Type: Case Reports; Clinical Conference; Journal Article |
Journal Detail:
|
Title: Nephron Volume: 83 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1999 |
Date Detail:
|
Created Date: 1999-12-20 Completed Date: 1999-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 202-13 Citation Subset: IM |
Affiliation:
|
Klinikum der Universität Heidelberg, Sektion Nephrologie, Heidelberg, Deutschland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin-Converting Enzyme Inhibitors / administration & dosage Antihypertensive Agents / administration & dosage*, adverse effects Blood Pressure / drug effects, physiology Blood Pressure Monitoring, Ambulatory Captopril / administration & dosage, adverse effects Diuretics / administration & dosage, adverse effects Doxazosin / administration & dosage, adverse effects Humans Hydrochlorothiazide / administration & dosage, adverse effects Hypertension, Renal / drug therapy*, physiopathology Kidney Failure, Chronic / complications*, physiopathology Kidney Glomerulus / blood supply*, chemistry, physiopathology Male Nitrendipine / administration & dosage, adverse effects Proteinuria / drug therapy, physiopathology Receptors, Angiotensin / antagonists & inhibitors Renal Circulation / drug effects Triamterene / administration & dosage, adverse effects |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Diuretics; 0/Receptors, Angiotensin; 39562-70-4/Nitrendipine; 396-01-0/Triamterene; 58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril; 74191-85-8/Doxazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Natriuretic peptide receptors of type A in human neuroblastomas.
Next Document: Association of a novel 3-amino acid deletion mutation of apolipoprotein E (Apo E Tokyo) with lipopro...