Document Detail

Antihypertensive therapy in patients above age 60. Third interim report of the European Working Party on High blood pressure in Elderly (EWPHE).
MedLine Citation:
PMID:  356497     Owner:  NLM     Status:  MEDLINE    
Three hundred forty nine hypertensive patients above the age of 60 have entered the double-blind multicentre trial of the European Working Party on High blood pressure in the Elderly (EWPHE). After stratification and randomisation half were treated with one or two capsules containing 25 mg hydrochlorothiazide and 50 mg triamterene and if blood pressure control was insufficient methyldopa was added up to 2 g daily; the other half received matching placebo. No significant differences between the groups were present prior to randomisation. A significant blood pressure difference of 25/10 mm Hg was obtained between the groups and maintained during two years of follow-up. No major disturbances in serum potassium or serum sodium were noted with the present drug combination. However, during the initial phase an increase in serum creatinine and serum uric acid was noted in the actively treated group, which was maintained for two years. Also glucose tolerance was impaired after 2 years in the actively treated group. A favourable influence on prognosis by active treatment can be expected on the basis of the blood pressure reduction and in the absence of major electrolytes disturbances. But this benefit must be proven by observed statistical differences in terminating events between the groups. Therefore the patients are being followed for a longer period of time and more patients are admitted into the trial.
A Amery; P Berthaux; W Birkenhäger; A Boel; P Brixko; C Bulpitt; D Clement; M Deruyttere; A de Schaepdryver; C Dollery; R Fagard; F Forette; J F Henry; J Hellemans; U Laaser; P Lund-Johansen; J MacFarlane; T Maling; A Mutsers; A Nissinen; O H Ohn; J Pelemans; A I Suchettkaye; J Tuomilehto; J Willems
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta cardiologica     Volume:  33     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  1978  
Date Detail:
Created Date:  1978-10-18     Completed Date:  1978-10-18     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  113-34     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Body Weight
Clinical Trials as Topic
Creatinine / blood
Double-Blind Method
Hydrochlorothiazide / therapeutic use*
Hypertension / drug therapy*
Methyldopa / therapeutic use
Middle Aged
Potassium / blood
Random Allocation
Sodium / blood
Triamterene / therapeutic use*
Uric Acid / blood
Reg. No./Substance:
396-01-0/Triamterene; 555-30-6/Methyldopa; 58-93-5/Hydrochlorothiazide; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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