Document Detail


Antihypertensive role of glossopharyngeal nerve stimulation by nifedipine using as calcium channel blocking agent in hypertension: an experimental study.
MedLine Citation:
PMID:  20091275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nifedipine is a therapeutic drug in acute attacks of hypertension because of its rapid absorption from oral mucosa. Taste receptors are innervated by glossopharyngeal nerves (GPN) as well as by facial and vagal nerves. Sensory neurons of the GPNs are localised in the petrous ganglion (PG). Transection of the taste sensitive GPN fibres causes taste bud and PG degeneration and spontaneous hypertension. In this study, the role of chemical stimulation of the taste buds of the GPN by nifedipine and its role in treatment of hypertension were investigated in rabbits. Nifedipine was dropped sublingually (20 mg) for 4 days in the study group, followed by measuring blood pressures again. Then, the lingual branches of GPNs were cut. One month later, blood pressures were measured for 4 days. All animals were sacrificed humanely at the end of the experiment, and normal and degenerated neuron densities in the petrosal ganglions were enumerated stereologically. The antihypertensive effect of nifedipine decreased after GPNs denervation, in accordance with the increase of degenerated neurons in the PG. The chemical stimulation of taste buds of the GPNs by nifedipine may be an important effect of nifedipine application in addition to its calcium channel blocking effect. The rapid decrease in blood pressure following sublingual use of nifedipine may also result from the direct stimulation of taste buds innervated by the GPNs.
Authors:
Mehmet Dumlu Aydin; Ednan Bayram; Zekai Halici; Nazan Aydin; Canan Atalay; Hizir Ulvi; Dilcan Kotan; Cemal Gundogdu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  32     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1607-11     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Medical Faculty, Ataturk University, Erzurum, Turkey. nmda11@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Sublingual
Animals
Antihypertensive Agents / administration & dosage,  pharmacology
Blood Pressure / drug effects
Calcium Channel Blockers / administration & dosage,  pharmacology*
Ganglia, Sensory / drug effects,  metabolism
Glossopharyngeal Nerve / drug effects*,  metabolism
Hypertension / drug therapy*
Nifedipine / administration & dosage,  pharmacology*
Rabbits
Taste Buds / metabolism
Tongue / innervation,  metabolism
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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