Document Detail

Antihypertensive and hormonal activity of MK 954 in spontaneously hypertensive rats.
MedLine Citation:
PMID:  1396995     Owner:  NLM     Status:  MEDLINE    
MK 954 (DuP 753), a recently developed angiotensin II (Ang II) receptor antagonist, was administered orally for 2 weeks to spontaneously hypertensive (SHR) and Wistar-Kyoto rats (WKY). Whereas the basal levels of plasma Ang II were lower in SHR than in WKY, treatment with MK 954 markedly reduced blood pressure in SHR but not in WKY. Plasma renin activity, Ang I and Ang II were increased, while plasma aldosterone was decreased in both strains. These results no only indicate therapeutic efficacy of this agent in the chronic treatment of human hypertension, but also support the idea that the renin-angiotensin system plays an important role in the control of blood pressure in SHR.
K Mizuno; S Niimura; M Tani; H Haga; T Gomibuchi; H Sanada; S Fukuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  215     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
Third Department of Internal Medicine, Fukushima Medical College, Japan.
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MeSH Terms
Angiotensin I / blood
Angiotensin II / antagonists & inhibitors*,  blood
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antihypertensive Agents / pharmacology*
Biphenyl Compounds / pharmacology*
Hormones / blood*
Hypertension / physiopathology*
Imidazoles / pharmacology*
Rats, Inbred SHR
Rats, Inbred WKY
Renin / blood
Renin-Angiotensin System / drug effects
Tetrazoles / pharmacology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Hormones; 0/Imidazoles; 0/Tetrazoles; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 9041-90-1/Angiotensin I; EC

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