Document Detail


Antihypertensive efficacy and tolerability of once-daily sustained-release diltiazem alone and in combination with ramipril in hypertension.
MedLine Citation:
PMID:  10778687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed once-daily (OD), sustained-release (SR) diltiazem alone and in combination with ramipril in essential hypertension. Fifty patients with supine diastolic blood pressure (DBP) > or = 95-< or = 114 mm Hg were entered into the active treatment phase of the study after 2 weeks of placebo run-in. Sustained-release diltiazem 180 mg OD was administered for 2 weeks, then optimally titrated, at 2 week intervals, to SR diltiazem 240 mg OD and then SR diltiazem 180 mg + ramipril 2.5 mg OD to achieve supine DBP < or = 90 mm Hg. After 4 weeks of diltiazem monotherapy (SR diltiazem 180 mg or 240 mg OD) mean supine DBP was reduced from 102.84 +/- 3.81 mm Hg to 90.15 +/- 5.02 mm Hg (P < 0.01) and mean supine heart rate was reduced from 85.15 +/- 11.02 bpm to 77.62 +/- 11.45 bpm (p < 0.01). Diltiazem monotherapy reduced supine DBP to < or = 90 mm Hg in 35/45 (77.77%) patients. Combination therapy (SR diltiazem 180 mg + ramipril 2.5 mg OD), received by non-responders to diltiazem monotherapy, reduced supine DBP to < or = 90 mm Hg in 3/10 (30%) patients. Sinus bradycardia was observed in one patient. Sustained-release diltiazem alone and in combination with ramipril reduce blood pressure in a dose related manner and is well tolerated.
Authors:
R Tuteja; D Swarup; G N Saxena; S Bhandari; P Sharma
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  47     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-05-24     Completed Date:  2000-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  962-5     Citation Subset:  IM    
Affiliation:
Upgraded Dept. of Medicine, SMS Medical College and Hospital, Jaipur.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antihypertensive Agents / administration & dosage*,  adverse effects
Blood Pressure / drug effects
Delayed-Action Preparations
Diltiazem / administration & dosage*,  adverse effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Hypertension / drug therapy*
Male
Middle Aged
Ramipril / administration & dosage*,  adverse effects
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Delayed-Action Preparations; 42399-41-7/Diltiazem; 87333-19-5/Ramipril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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