Document Detail


Antihypertensive effects of a novel peripheral vasodilator, Ro 12-4713.
MedLine Citation:
PMID:  7286027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of Ro 12-4713, a vasodilator, on blood pressure and heart rate, were tested in 13 ambulant patients with mild to severe hypertension. The patients received Ro 12-4713 in total oral doses ranging from 1.5 to 4 mg/kg over a 3-5 day period. Standard laboratory tests were done 24 h before and after the study. Standing and supine blood pressure and heart rate were determined before, and every hour for 6-8 h after drug administration. ECGs were recorded before, during and at the end of each study day. Ro 12-4713 reduced the pretreatment standing and supine-blood pressure from 213 +/- 34/126 +/- 21 mmHg and 218 +/- 31/130 +/- 20 mmHg to 156 +/- 33/85 +/- 9 mmHg and 158 +/- 25/88 +/- 11 mmHg at the end of Day 5. Heart rate was only transiently increased in patients with pretreatment values of less than 90 beats/min. Although abnormal ECGs tended towards normalization, there were 2 cases of T-wave inversion (the patients remained asymptomatic). Raised BUN levels tended to decrease towards normal. Side effects reported spontaneously by patients (headaches, palpitations, dizziness, nausea and one case of water retention) appeared to be transient in nature. Ro 12-4713 appeared to be a very potent and long lasting antihypertensive agent, whose inherent side effects were only transient in nature.
Authors:
D Chu; G Cocco; C Strozzi; R Vallini; M Nonato; R Amrein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  19     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Antihypertensive Agents / adverse effects,  therapeutic use*
Blood Pressure / drug effects
Drug Evaluation
Electrocardiography
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy
Male
Middle Aged
Pyrimidines / therapeutic use*
Vasodilator Agents / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Pyrimidines; 0/Vasodilator Agents; 68020-77-9/carprazidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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