Document Detail


Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat.
MedLine Citation:
PMID:  2459509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute as well as chronic treatment with ketanserin but not with ritanserin reduced the blood pressure in the spontaneously hypertensive rat, indicating that 5-HT2-receptor blockade alone does not have antihypertensive properties. Whereas the blood pressure reduction to acute administration of ketanserin was directly related to its ability to shift the dose-response curve of phenylephrine (alpha 1-adrenergic blockade), the same relationship was not apparent following chronic treatment with ketanserin. This suggests that the 5-HT2- and alpha 1-blockade may complement each other in reducing the blood pressure, a conclusion supported by the observation that in the conscious rat, 5-HT2-receptor blockade by ritanserin enhanced the hypotensive response to prazosin. However, ritanserin did not influence the ability of prazosin to antagonize pressor responses to phenylephrine in the pithed rat.
Authors:
B Persson; K Gradin; A Pettersson; T Hedner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  11 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-11-17     Completed Date:  1988-11-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S22-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Ketanserin / therapeutic use*
Male
Phenylephrine / pharmacology
Piperidines / therapeutic use*
Prazosin / pharmacology
Rats
Rats, Inbred SHR
Receptors, Adrenergic, alpha / drug effects,  physiology
Receptors, Serotonin / drug effects,  physiology
Ritanserin
Serotonin / pharmacology
Sympathetic Nervous System / drug effects,  physiopathology
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperidines; 0/Receptors, Adrenergic, alpha; 0/Receptors, Serotonin; 19216-56-9/Prazosin; 50-67-9/Serotonin; 59-42-7/Phenylephrine; 74050-98-9/Ketanserin; 87051-43-2/Ritanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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