| Antihypertensive effects of hydrolysates of wakame (Undaria pinnatifida) and their angiotensin-I-converting enzyme inhibitory activity. | |
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MedLine Citation:
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PMID: 12464726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The angiotensin-I-converting enzyme (ACE) inhibitory and antihypertensive activities of wakame hydrolysates have been investigated in several studies. METHODS: Wakame (Undaria pinnatifida) was hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for ACE was measured. Of these hydrolysates 4 with potent ACE inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHR). RESULTS: The systolic blood pressure of SHR decreased significantly after single oral administration of protease S 'Amano' and proleather FG-F hydrolysates (10 mg protein/kg body weight). In a long-term feeding experiment, 7-week-old SHR were fed standard chow supplemented with protease S 'Amano'-derived wakame hydrolysates for 10 weeks. In SHR fed the 1 and 0.1% wakame hydrolysates, elevation of systolic blood pressure was still significantly suppressed for 7 weeks. CONCLUSIONS: The hydrolysates derived from wakame by protease S 'Amano' have a powerful ACE-inhibitory activity (IC(50) = 86 microg protein/ml) and were effective in spite of their slight bitterness as 'physiologically functional food' with antihypertensive activity. |
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Authors:
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Minoru Sato; Takashi Oba; Toshiyasu Yamaguchi; Toshiki Nakano; Takashi Kahara; Katsura Funayama; Akio Kobayashi; Takahisa Nakano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 46 ISSN: 0250-6807 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-12-04 Completed Date: 2003-04-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 259-67 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Laboratory of Marine Biochemistry, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan. msato@bios.tohoku.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Animals Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects Digestion Hydrolysis Hypertension / drug therapy* Kinetics Male Rats Rats, Inbred SHR Seaweed / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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