Document Detail

Antihypertensive effects of hydrolysates of wakame (Undaria pinnatifida) and their angiotensin-I-converting enzyme inhibitory activity.
MedLine Citation:
PMID:  12464726     Owner:  NLM     Status:  MEDLINE    
AIM: The angiotensin-I-converting enzyme (ACE) inhibitory and antihypertensive activities of wakame hydrolysates have been investigated in several studies. METHODS: Wakame (Undaria pinnatifida) was hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for ACE was measured. Of these hydrolysates 4 with potent ACE inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHR). RESULTS: The systolic blood pressure of SHR decreased significantly after single oral administration of protease S 'Amano' and proleather FG-F hydrolysates (10 mg protein/kg body weight). In a long-term feeding experiment, 7-week-old SHR were fed standard chow supplemented with protease S 'Amano'-derived wakame hydrolysates for 10 weeks. In SHR fed the 1 and 0.1% wakame hydrolysates, elevation of systolic blood pressure was still significantly suppressed for 7 weeks. CONCLUSIONS: The hydrolysates derived from wakame by protease S 'Amano' have a powerful ACE-inhibitory activity (IC(50) = 86 microg protein/ml) and were effective in spite of their slight bitterness as 'physiologically functional food' with antihypertensive activity.
Minoru Sato; Takashi Oba; Toshiyasu Yamaguchi; Toshiki Nakano; Takashi Kahara; Katsura Funayama; Akio Kobayashi; Takahisa Nakano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  46     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2002  
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-04-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Laboratory of Marine Biochemistry, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan.
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MeSH Terms
Administration, Oral
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Hypertension / drug therapy*
Rats, Inbred SHR
Seaweed / chemistry*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents

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