Document Detail

Antihypertensive effects of a dietary unsaturated FA mixture in spontaneously hypertensive rats.
MedLine Citation:
PMID:  12120954     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate whether a mixture of dietary n-6 and n-3 PUFA could lower blood pressure in spontaneously hypertensive rats (SHR) of different ages. In addition, we studied how such a treatment could normalize the FA composition of plasma TAG and cholesterol esters (CE), and of red blood cell (RBC) total lipids. SHR (ages 4, 19, and 50 wk) were fed a normal diet (control groups) or a semisynthetic diet containing a mixture of gamma-linolenic acid (GLA), EPA, and DHA (experimental groups). Systolic blood pressure was measured at regular intervals. After 11 wk of consuming this diet, plasma TAG and CE were separated by TLC and analyzed for their FA composition. Total FA composition of RBC was also determined. The degree to which blood pressure was elevated was reduced in SHR after 11 wk of diet. The largest decrease was obtained with the oldest animals. In RBC, EPA and DHA contents increased. In plasma TAG and CE, EPA, DHA, and GLA increased whereas arachidonic acid decreased. The n-6 and n-3 unsaturated FA mix slowed the development of hypertension in young SHR and decreased blood pressure in adult and aged SHR. In addition, the present treatment altered the n-3 and n-6 PUFA content of SHR lipids to that seen in normotensive rats.
S Bellenger-Germain; J P Poisson; M Narce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  37     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-7     Citation Subset:  IM    
UPRES Lipides et Nutrition, Faculté des Sciences Gabriel, Université de Bourgogne, Dijon, France.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  pharmacology*
Blood Pressure
Body Weight
Erythrocyte Membrane / metabolism
Fatty Acids / blood
Fatty Acids, Unsaturated / administration & dosage,  pharmacology*
Feeding Behavior
Rats, Inbred SHR
Reg. No./Substance:
0/Antihypertensive Agents; 0/Fatty Acids; 0/Fatty Acids, Unsaturated

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