Document Detail


Antihypertensive effects of captopril without adverse effects on glucose tolerance in hyperinsulinemic rhesus monkeys.
MedLine Citation:
PMID:  7563005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rhesus monkey (Macaca mulatta), which has been found to develop spontaneous obesity, non-insulin dependent diabetes mellitus (NIDDM; Type 2), and hypertension, was used to evaluate the potential blood pressure-lowering effects of captopril as well as the specific effects, if any, on the prediabetic state. Intravenous and oral glucose tolerance testing was carried out with oral captopril dosing. Results showed that captopril significantly decreased both systolic and diastolic blood pressure in all monkeys and significantly decreased fasting plasma glucose levels. Based on these preliminary studies in monkeys, we conclude that captopril exerted antihypertensive effects without adverse effects on glucose metabolism.
Authors:
N L Bodkin; B C Hansen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medical primatology     Volume:  24     ISSN:  0047-2565     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-10-27     Completed Date:  1995-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
School of Medicine, Dept. of Physiology, University of Maryland at Baltimore, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / adverse effects,  pharmacology*
Blood Glucose / drug effects,  metabolism*
Blood Pressure / drug effects*
Captopril / adverse effects,  pharmacology*
Diabetes Mellitus, Type 2 / blood
Diastole / drug effects
Glucose Tolerance Test*
Hyperinsulinism*
Hypertension / drug therapy,  physiopathology
Macaca mulatta
Male
Systole / drug effects
Grant Support
ID/Acronym/Agency:
DK 37717/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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