Document Detail


Antihypertensive effects of S9490-3, a new converting enzyme inhibitor, in the conscious spontaneously hypertensive rat.
MedLine Citation:
PMID:  3006975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute and chronic cardiovascular effects of S9490-3, a new converting enzyme inhibitor, were studied by means of a computerized analysis of the intra-aortic blood pressure recorded for 48 consecutive hours, in the conscious, unrestrained adult spontaneously hypertensive rat (SHR). The software used allowed the simultaneous study of one control and one treated animal. A single intravenous dose of S9490-3 (2 mg/kg) induced a rapid fall in systolic and diastolic blood pressure, which remained significant for 11 h. This decrease was not associated with an elevation in heart rate. A chronic oral treatment with S9490-3 (1 mg/kg/24 h for 12 days) significantly lowered systolic and diastolic blood pressure and reduced the variability of systolic blood pressure. The heart rate was slightly increased at rest (day time) but significantly elevated in the freely exercising SHR (night time). However, it must be noted that this increase remained moderate. The baroreflex sensitivity of chronically treated animals was enhanced when measured after phenylephrine but not after nitroglycerine bolus. Chronically given S9490-3 significantly reduced the pressor effect of phenylephrine and decreased the left ventricle weight.
Authors:
C Barres; C Cerutti; C Z Paultre; J Sassard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  70     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-01     Completed Date:  1986-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Blood Pressure / drug effects
Drug Administration Schedule
Heart Rate / drug effects
Hypertension / drug therapy*
Indoles / administration & dosage,  therapeutic use*
Injections, Intravenous
Male
Oligopeptides / therapeutic use*
Perindopril
Rats
Rats, Inbred SHR
Teprotide
Chemical
Reg. No./Substance:
0/Indoles; 0/Oligopeptides; 35115-60-7/Teprotide; 82834-16-0/Perindopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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