| Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 20448636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ocimum basilicum L. (OBL), sweet basil, is a medicinal herb used in traditional Chinese medicine to treat cardiovascular diseases including hypertension. The objective of the study was to investigate the possible antihypertensive effects of OBL extract in renovascular hypertensive rats. The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. Rats were randomized into sham, untreated 2K1C, captopril- (30 mg kg(-1) per day orally) and OBL- (100, 200, 400 mg kg(-1) per day orally) (low (L)-, medium (M)-, high (H)-OBL) treated 2K1C groups (n=10-12 per group), followed up for 4 weeks. Blood pressure, heart weight/body weight, plasma angiotensin-II and endothelin (ET)-1 were studied. OBL reduced systolic and diastolic blood pressure by about 20 and 15 mm Hg, respectively, compared with 35 and 22 mm Hg for captopril, from the lowest dose tested with no dose dependency. Cardiac hypertrophy was reduced from 3.6+/-0.7 mg g(-1) for untreated 2K1C to 3.0+/-0.6, 2.9+/-0.6 and 2.4+/-0.4 mg g(-1) for L-, M- and H-OBL, respectively, compared with 2.6+/-0.5 for sham and 3.1+/-0.4 mg g(-1) for captopril (P<0.05). Renal function was improved with captopril. Angiotensin was reduced to a lesser extent than with captopril. ET was reduced to lower concentrations (78+/-15, 80+/-22, 82+/-15 pg ml(-1) for L-, M-, H-OBL, respectively) than in sham (116+/-31 pg ml(-1)), untreated 2K1C (174+/-72 pg ml(-1)) or captopril (117+/-72 pg ml(-1)) groups. The effects of OBL on blood pressure, cardiac hypertrophy and ET, are consistent with an effect on ET-converting enzyme, and warrant further exploration. |
| | |
Authors:
|
Anwar Umar; Guzelnur Imam; Wuliya Yimin; Parhat Kerim; Ibadet Tohti; Bénédicte Berké; Nicholas Moore |
Related Documents
:
|
3005576 - Angiotensin converting enzyme inhibitors as antihypertensive agents: 1-[(2-mercaptocycl... 8590256 - Effect of captopril on ocular irritative response to topical neutral formaldehyde and y... 1312296 - Angiotensin-converting enzyme in renal and cerebral tissue and implications for success... 1536736 - Captopril test in children with reflux nephropathy. 9825266 - Steady-state trough plasma mibefradil concentrations and correlation to blood pressure ... 16687966 - Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for l... |
Publication Detail:
|
Type: Journal Article Date: 2010-05-07 |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 33 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-05 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
|
Languages: eng Pagination: 727-30 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Xinjiang Medical University, Urumqi, Xinjiang, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
blood Animals Antihypertensive Agents / therapeutic use* Aspartic Acid Endopeptidases / antagonists & inhibitors Blood Pressure / drug effects* Captopril / therapeutic use Cardiomegaly / drug therapy Disease Models, Animal Endothelin-1 / blood Hypertension, Renovascular / drug therapy* Kidney / drug effects, physiology Male Metalloendopeptidases / antagonists & inhibitors Ocimum basilicum* Plant Extracts / therapeutic use* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Endothelin-1; 0/Plant Extracts; 11128-99-7/Angiotensin II; 62571-86-2/Captopril; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.71/endothelin-converting enzyme |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactiv...
Next Document: Not sleeping well can damage your heart.