Document Detail


Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats.
MedLine Citation:
PMID:  20448636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ocimum basilicum L. (OBL), sweet basil, is a medicinal herb used in traditional Chinese medicine to treat cardiovascular diseases including hypertension. The objective of the study was to investigate the possible antihypertensive effects of OBL extract in renovascular hypertensive rats. The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. Rats were randomized into sham, untreated 2K1C, captopril- (30 mg kg(-1) per day orally) and OBL- (100, 200, 400 mg kg(-1) per day orally) (low (L)-, medium (M)-, high (H)-OBL) treated 2K1C groups (n=10-12 per group), followed up for 4 weeks. Blood pressure, heart weight/body weight, plasma angiotensin-II and endothelin (ET)-1 were studied. OBL reduced systolic and diastolic blood pressure by about 20 and 15 mm Hg, respectively, compared with 35 and 22 mm Hg for captopril, from the lowest dose tested with no dose dependency. Cardiac hypertrophy was reduced from 3.6+/-0.7 mg g(-1) for untreated 2K1C to 3.0+/-0.6, 2.9+/-0.6 and 2.4+/-0.4 mg g(-1) for L-, M- and H-OBL, respectively, compared with 2.6+/-0.5 for sham and 3.1+/-0.4 mg g(-1) for captopril (P<0.05). Renal function was improved with captopril. Angiotensin was reduced to a lesser extent than with captopril. ET was reduced to lower concentrations (78+/-15, 80+/-22, 82+/-15 pg ml(-1) for L-, M-, H-OBL, respectively) than in sham (116+/-31 pg ml(-1)), untreated 2K1C (174+/-72 pg ml(-1)) or captopril (117+/-72 pg ml(-1)) groups. The effects of OBL on blood pressure, cardiac hypertrophy and ET, are consistent with an effect on ET-converting enzyme, and warrant further exploration.
Authors:
Anwar Umar; Guzelnur Imam; Wuliya Yimin; Parhat Kerim; Ibadet Tohti; Bénédicte Berké; Nicholas Moore
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Publication Detail:
Type:  Journal Article     Date:  2010-05-07
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  33     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  727-30     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Xinjiang Medical University, Urumqi, Xinjiang, PR China.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / blood
Animals
Antihypertensive Agents / therapeutic use*
Aspartic Acid Endopeptidases / antagonists & inhibitors
Blood Pressure / drug effects*
Captopril / therapeutic use
Cardiomegaly / drug therapy
Disease Models, Animal
Endothelin-1 / blood
Hypertension, Renovascular / drug therapy*
Kidney / drug effects,  physiology
Male
Metalloendopeptidases / antagonists & inhibitors
Ocimum basilicum*
Plant Extracts / therapeutic use*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelin-1; 0/Plant Extracts; 11128-99-7/Angiotensin II; 62571-86-2/Captopril; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.71/endothelin-converting enzyme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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