Document Detail

Antihypertensive effect of a non-selective (propranolol) and a cardioselective (metoprolol) beta-adrenoceptor blocking agent at rest and during exercise.
MedLine Citation:
PMID:  375959     Owner:  NLM     Status:  MEDLINE    
1 The antihypertensive effects at rest and during physical exercise of the non-selective beta-adrenoceptor blocker propranolol and the cardioselective beta-adrenoceptor blocker metoprolol were compared in a double-blind cross-over study. 2 Eighteen patients with mild hypertension entered the trial. One patient was withdrawn from the study due to side effects on both drugs. 3 The two beta-adrenoceptor blockers were compared using doses earlier shown to have the same beta-adrenoceptor blocking potency, as measured by their effect on exercise tachycardia in healthy men. 4 Arterial blood pressure was reduced to the same extent by propranolol and metoprolol at rest as well as during submaximal work. 5 It is concluded that the antihypertensive effect of beta-adrenoceptor blockers is mainly mediated through blockade of the beta 1-adrenoceptors.
N Clausen; T Damsgaard; K Mellemgaard
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  7     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-08-16     Completed Date:  1979-08-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  379-83     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents*
Blood Pressure / drug effects
Clinical Trials as Topic
Double-Blind Method
Exercise Test
Hypertension / physiopathology
Metoprolol / adverse effects,  pharmacology*
Patient Compliance
Physical Exertion*
Propanolamines / pharmacology*
Propranolol / adverse effects,  pharmacology*
Pulse / drug effects
Reg. No./Substance:
0/Antihypertensive Agents; 0/Propanolamines; 37350-58-6/Metoprolol; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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