Document Detail

Antihypertensive effect of low-frequency transcutaneous electrical nerve stimulation (TENS) in comparison with drug treatment.
MedLine Citation:
PMID:  22563948     Owner:  NLM     Status:  MEDLINE    
Hypertension is a major risk factor for vascular disease, yet blood pressure (BP) control is unsatisfactory low, partly due to side-effects. Transcutaneous electrical nerve stimulation (TENS) is well tolerated and studies have demonstrated BP reduction. In this study, we compared the BP lowering effect of 2.5 mg felodipin once daily with 30 min of bidaily low-frequency TENS in 32 adult hypertensive subjects (mean office BP 152.7/90.0 mmHg) in a randomized, crossover design. Office BP and 24-h ambulatory BP monitoring (ABPM) were performed at baseline and at the end of each 4-week treatment and washout period. Felodipin reduced office BP by 10/6 mmHg (p <0.001 respectively) and after washout BP rose to a level still significantly lower than at baseline. TENS reduced office BP by 5/1.5 mmHg (p <0.01, ns). After TENS washout, BP was further reduced and significantly lower than at baseline, but at levels similar to BP after felodipin washout and therefore reasonably caused by factors other than the treatment per se. ABPM revealed a significant systolic reduction of 3 mmHg by felodipin, but no significant changes were noted after TENS. We conclude that our study does not present any solid evidence of BP reduction of TENS.
Jonas Silverdal; Georgios Mourtzinis; Elisabet Stener-Victorin; Clas Mannheimer; Karin Manhem
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-05-08
Journal Detail:
Title:  Blood pressure     Volume:  21     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-27     Completed Date:  2013-04-24     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
Department of Internal Medicine and Geriatrics, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure Determination
Calcium Channel Blockers / therapeutic use*
Cross-Over Studies
Felodipine / therapeutic use*
Hypertension / diagnosis,  drug therapy,  physiopathology,  therapy*
Middle Aged
Prospective Studies
Risk Factors
Transcutaneous Electric Nerve Stimulation / instrumentation,  methods*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 72509-76-3/Felodipine
Comment In:
Blood Press. 2013 Jun;22(3):188-9   [PMID:  23004921 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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