Document Detail

Antihypertensive effect of gamma-amino butyric acid enriched soy products in spontaneously hypertensive rats.
MedLine Citation:
PMID:  15630275     Owner:  NLM     Status:  MEDLINE    
The effect of gamma-amino butyric acid (GABA)-enriched soybean on blood pressure was investigated in male spontaneously hypertensive rats. Ten-week-old rats were given diets containing graded levels of GABA-enriched soybean powder for 8 weeks. The systolic blood pressure in rats fed 0.15% GABA diet was significantly lower at 1st week and maintained lower values for 4 weeks as compared with 0% GABA controls. No effect on blood pressure was found in those of 0.03 and 0.3% GABA. The results suggest that there exist appropriate dietary GABA level to get the blood pressure lowering effect.
F Shizuka; Y Kido; T Nakazawa; H Kitajima; C Aizawa; H Kayamura; N Ichijo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  22     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:  2004  
Date Detail:
Created Date:  2005-01-04     Completed Date:  2005-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-7     Citation Subset:  IM    
Department of Living Sciences, Nagano Prefectural College, 8-49-7 Miwa, Nagano-City, 380-8525, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Dietary Supplements
Hypertension / drug therapy*
Rats, Inbred SHR
Systole / drug effects
gamma-Aminobutyric Acid / pharmacology*
Reg. No./Substance:
0/Antihypertensive Agents; 56-12-2/gamma-Aminobutyric Acid

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