Document Detail


Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  18179728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biotin is a member of the vitamin B-complex family. Biotin deficiency has been associated with hyperglycaemia and insulin resistance in animals and humans. In the present study, we investigated the pharmacological effects of biotin on hypertension in the stroke-prone spontaneously hypertensive rat (SHRSP) strain. We observed that long-term administration of biotin decreased systolic blood pressure in the SHRSP strain; also, a single dose of biotin immediately decreased systolic blood pressure in this strain. Pretreatment with the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazole [4,3-alpha]quinoxalin-1-one abolished the hypotensive action of biotin in the SHRSP strain, while pretreatment with the NO synthase inhibitor NG-nitro-l-arginine methyl ester had no effect on the action of biotin. Biotin reduced coronary arterial thickening and the incidence of stroke in the SHRSP strain. These results suggest that the pharmacological dose of biotin decreased the blood pressure of the SHRSP via an NO-independent direct activation of soluble guanylate cyclase. Our findings reveal the beneficial effects of biotin on hypertension and the incidence of stroke.
Authors:
Mari Watanabe-Kamiyama; Shin Kamiyama; Kimiko Horiuchi; Kousaku Ohinata; Hitoshi Shirakawa; Yuji Furukawa; Michio Komai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-08
Journal Detail:
Title:  The British journal of nutrition     Volume:  99     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-06     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  756-63     Citation Subset:  IM    
Affiliation:
Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotin / analysis,  blood,  therapeutic use*
Coronary Vessels / pathology
Genetic Predisposition to Disease
Glucose Tolerance Test
Guanylate Cyclase / antagonists & inhibitors
Hypertension / drug therapy*,  pathology
Male
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide Synthase / antagonists & inhibitors
Oxadiazoles / pharmacology
Quinoxalines / pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Stroke / pathology,  prevention & control*
Time
Vitamins / analysis,  blood,  therapeutic use*
Chemical
Reg. No./Substance:
0/1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; 0/Oxadiazoles; 0/Quinoxalines; 0/Vitamins; 50903-99-6/NG-Nitroarginine Methyl Ester; 58-85-5/Biotin; EC 1.14.13.39/Nitric Oxide Synthase; EC 4.6.1.2/Guanylate Cyclase

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