| Antihypertensive effect of Iranian Crataegus curvisepala Lind.: a randomized, double-blind study. | |
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MedLine Citation:
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PMID: 15700749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to investigate the potential antihypertensive effects of extracts of the flavonoid-rich Iranian flower, Crataegus curvisepala Lind., a member of the Rosaceae family. The hydroalcoholic extract of the leaves and flowers were studied in a double-blind, placebo-controlled clinical trial to determine its effects. A total of 92 men and women with primary mild hypertension, aged 40-60 years, were selected and divided randomly into two groups, receiving either hydroalcoholic extract of C. curvisepala Lind. or placebo three times daily for more than 4 months. Blood pressure (BP) was measured each month. Statistical analysis was carried out using Student's t-test. The results obtained showed a significant decrease in both systolic and diastolic BP after 3 months (p < 0.05). C. curvisepala has a time-dependent antihypertensive effect. |
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Authors:
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S Asgary; G H Naderi; M Sadeghi; R Kelishadi; M Amiri |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Drugs under experimental and clinical research Volume: 30 ISSN: 0378-6501 ISO Abbreviation: Drugs Exp Clin Res Publication Date: 2004 |
Date Detail:
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Created Date: 2005-02-09 Completed Date: 2005-04-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802135 Medline TA: Drugs Exp Clin Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 221-5 Citation Subset: IM |
Affiliation:
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Isfahan Cardiovascular Research Center, Sedigheh Tahereh Hospital, Isfahan, Iran. bsr@mui.ac.ir |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / isolation & purification, therapeutic use* Crataegus* Double-Blind Method Female Flowers Humans Hypertension / drug therapy*, physiopathology Iran Male Middle Aged Plant Extracts / isolation & purification, therapeutic use Plant Leaves |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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