Document Detail


Antihypertensive effect of Eucommia ulmoides Oliv. extracts in spontaneously hypertensive rats.
MedLine Citation:
PMID:  20347950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: To investigate the antihypertensive fractions of Eucommia ulmoides Oliv. and their underlying mechanisms in spontaneously hypertensive rats (SHRs). MATERIALS AND METHODS: In vivo study, Eucommia ulmoides lignans (EuL) and Eucommia ulmoides iridoids (EuI) were administrated to Sprague-Dawley (SD) rats and SHRs, and their blood pressures were measured. Plasma level of nitric oxide (NO) was measured by colorimetric method, and renin activity (RA) and plasma concentration of angiotensin II (Ang II) were measured by radioimmunoassay. In vitro study, rat mesenteric artery was treated with EuL and the vessel relaxation responses were determined. RESULTS: EuL could lower blood pressures of both SD rats and SHR dose-dependently by either intravenous (i.v.) or intragastric (i.g.) administration, but EuI failed to affect blood pressure in the two kinds of rats. Meanwhile, no synergistic effect was observed with the combination of EuL and EuI. The plasma level of NO in SHR treated with EuL 300 mg/kg twice a day was markedly increased. Both plasma RA and Ang II level were decreased with long-term oral treatment of EuL 150 and 300 mg/kg twice a day. In perfusion experiment, EuL relaxed mesenteric artery quickly and dose-dependently and the effect on the artery with and without endothelium was the same. CONCLUSIONS: EuL may be the effective fraction to lowering blood pressure and its antihypertensive effect is probably associated with regulating NO and renin-angiotensin system (RAS) and directly relaxing artery.
Authors:
Li-fang Luo; Wei-hua Wu; Ying-jun Zhou; Jin Yan; Guo-ping Yang; Dong-sheng Ouyang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-27
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  129     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / blood
Animals
Antihypertensive Agents / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Eucommiaceae / chemistry*
Hypertension / blood,  drug therapy
Iridoids / pharmacology,  therapeutic use*
Male
Mesenteric Arteries / drug effects
Nitric Oxide / blood
Phytotherapy
Plant Bark
Plant Extracts / chemistry,  pharmacology,  therapeutic use*
Rats
Rats, Inbred SHR / blood*
Rats, Inbred WKY
Rats, Sprague-Dawley
Renin / blood
Vasodilation / drug effects*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Iridoids; 0/Plant Extracts; 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II; EC 3.4.23.15/Renin

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