Document Detail

Antihypertensive drugs and endothelial cell function.
MedLine Citation:
PMID:  8992496     Owner:  NLM     Status:  MEDLINE    
Arterial hypertension is associated with increased capillary permeability, a possible contributor to the vascular remodeling process which could be involved in certain pathological conditions arising from elevated blood pressure. This study evaluated the effects of various antihypertensive drugs on capillary permeability in the normal rat, using Evan's blue dye (EB) as a marker of albumin extravasation. The results reveal that acute injection of certain diuretics (furosemide, indapamide, hydrochlorothiazide) increase while others (amiloride, cicletanine) decrease capillary permeability via stimulation of the cyclooxygenase pathway. 10 day gavage with indapamide, amiloride and cicletanine, as well as angiotensin-converting enzyme (ACE) inhibitor perindopril and calcium channel blockers nifedipine and verapamil decreases capillary permeability, whereas furosemide, hydrochlorothiazide, ACE inhibitor captopril and calcium channel blocker clentiazem do not modify or increase EB extravasation. Hence, selected antihypertensive agents reduce capillary permeability and could therefore have a supplemental protective vascular effect, in addition to their lowering arterial pressure.
S Lehoux; G E Plante
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  54     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Québec, Canada.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antihypertensive Agents / pharmacology*
Calcium Channel Blockers / pharmacology
Capillary Permeability / drug effects*
Coloring Agents
Diuretics / pharmacology
Endothelium, Vascular / drug effects*,  physiology
Enzyme Activation / drug effects
Evans Blue
Indomethacin / pharmacology
Prostaglandin-Endoperoxide Synthases / metabolism
Serum Albumin
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Coloring Agents; 0/Diuretics; 0/Serum Albumin; 314-13-6/Evans Blue; 53-86-1/Indomethacin; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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