Document Detail


Antihypertensive drugs: diuretics and betablockers are the best assessed.
MedLine Citation:
PMID:  10558453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
(1) In trials involving hypertensive non diabetic patients under 65, some diuretics and betablockers have prevented strokes, without conferring protection from coronary events or death. In one trial captopril had an effect comparable to that of diuretics or betablockers in terms of overall cardiovascular prevention, but was a little less effective in preventing strokes. (2) In trials involving hypertensive subjects over 65, some diuretics and betablockers have reduced the risk of stroke, coronary events, heart failure, and death. In one trial a diuretic was superior to a betablocker in terms of preventive efficacy and adverse effects. Nitrendipine, in combination with other antihypertensive drugs, prevented strokes in one trial. (3) In a trial involving hypertensive diabetic patients, captopril and atenolol reduced the risk of stroke, heart failure and worsening of retinal disease, without preventing coronary events or death. In two trials coronary events were more frequent on dihydropyridine than on an angiotensin-coverting-enzyme (ACE) inhibitor. (4) In one trial a diuretic reduced the risk of relapse after stroke, even in patients without severe hypertension.
Authors:
-
Related Documents :
1449293 - Combined carotid and coronary revascularization: the preferred approach to the severe v...
9619493 - The stroke pharmacopeia: current medical therapies.
8072023 - Longitudinal changes in myocardial basic fibroblast growth factor (fgf-2) activity foll...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  8     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-11-09     Completed Date:  1999-11-09     Revised Date:  2010-12-27    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  T    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Adult
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents* / adverse effects,  therapeutic use
Calcium Channel Blockers / therapeutic use
Cerebrovascular Disorders / etiology,  prevention & control
Diabetes Mellitus, Type 2 / complications,  drug therapy
Diuretics / therapeutic use
Female
Humans
Hypertension / complications,  drug therapy*
Male
Middle Aged
Randomized Controlled Trials as Topic
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Diuretics
Comments/Corrections
Comment In:
Prescrire Int. 2010 Oct;19(109):237; discussion 237-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lipomatosis due to chronic steroid therapy.
Next Document:  Notice inviting applications for new award for fiscal year 1999. The Office of the Assistant Secret...