Document Detail

Antihypertensive drugs: diuretics and betablockers are the best assessed.
MedLine Citation:
PMID:  10558453     Owner:  NLM     Status:  MEDLINE    
(1) In trials involving hypertensive non diabetic patients under 65, some diuretics and betablockers have prevented strokes, without conferring protection from coronary events or death. In one trial captopril had an effect comparable to that of diuretics or betablockers in terms of overall cardiovascular prevention, but was a little less effective in preventing strokes. (2) In trials involving hypertensive subjects over 65, some diuretics and betablockers have reduced the risk of stroke, coronary events, heart failure, and death. In one trial a diuretic was superior to a betablocker in terms of preventive efficacy and adverse effects. Nitrendipine, in combination with other antihypertensive drugs, prevented strokes in one trial. (3) In a trial involving hypertensive diabetic patients, captopril and atenolol reduced the risk of stroke, heart failure and worsening of retinal disease, without preventing coronary events or death. In two trials coronary events were more frequent on dihydropyridine than on an angiotensin-coverting-enzyme (ACE) inhibitor. (4) In one trial a diuretic reduced the risk of relapse after stroke, even in patients without severe hypertension.
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  8     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-11-09     Completed Date:  1999-11-09     Revised Date:  2010-12-27    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  T    
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents* / adverse effects,  therapeutic use
Calcium Channel Blockers / therapeutic use
Cerebrovascular Disorders / etiology,  prevention & control
Diabetes Mellitus, Type 2 / complications,  drug therapy
Diuretics / therapeutic use
Hypertension / complications,  drug therapy*
Middle Aged
Randomized Controlled Trials as Topic
Treatment Outcome
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Diuretics
Comment In:
Prescrire Int. 2010 Oct;19(109):237; discussion 237-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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